One-pot sequential four-component coupling via Cp*RuCl-catalyzed cyclotrimerization and Suzuki–Miyaura coupling

Autor:	Hisao Nishiyama, Yoshihiko Yamamoto, Jun‐ichi Ishii, Kenji Itoh
Rok vydání:	2005
Předmět:	Aqueous solution Aryl Organic Chemistry Intermolecular force chemistry.chemical_element General Medicine Biochemistry Toluene Combinatorial chemistry Ruthenium Catalysis chemistry.chemical_compound chemistry Drug Discovery Propargyl Organic chemistry Selectivity
Zdroj:	Tetrahedron. 61:11501-11510
ISSN:	0040-4020
DOI:	10.1016/j.tet.2005.08.069
Popis:	The catalytic intermolecular cyclotrimerization of alkynylboronates, propargyl alcohols, and terminal alkynes was accomplished by means of the ruthenium catalysis and the temporary tethering approach with the C–B–O linkage to give rise to highly substituted arylboronates with excellent selectivity. The resultant arylboronates were further converted to highly substituted biaryls via the Suzuki–Miyaura coupling with various aryl iodides using Pd 2 (dba) 3 /PCy 3 as a catalyst precursor in aqueous toluene. As a consequence, the four-component coupling approach to highly substituted biaryls was successfully established by combining these two operations into a sequential one-pot process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896bb101e573970b20835f8d550b1312 https://doi.org/10.1016/j.tet.2005.08.069 Zobrazit plný text záznamu Full Text from ScienceDirect