Liver metabolic activity changes over time with neoadjuvant therapy in locally advanced rectal cancer

Autor:	Murat Koç, Yusuf Demir, Gamze Çapa Kaya, Erdem Sürücü, Tarık Şengöz
Rok vydání:	2015
Předmět:	Male positron emission tomography Time Factors genetic structures Colorectal cancer retrospective study very elderly medicine.medical_treatment multimodal imaging Multimodal Imaging adjuvant chemoradiotherapy 030218 nuclear medicine & medical imaging computer assisted tomography 0302 clinical medicine time factor middle aged Medicine Locally advanced rectal cancer Neoadjuvant therapy Standardized uptake value Aged 80 and over medicine.diagnostic_test 18F-FDG PET/CT General Medicine Middle Aged Neoadjuvant Therapy fluorodeoxyglucose f 18 female Liver Positron emission tomography scintiscanning 030220 oncology & carcinogenesis Female Metabolic activity Adult medicine.medical_specialty radiation response Locally advanced Urology liver Aged Chemoradiotherapy Adjuvant Fluorodeoxyglucose F18 Humans Liver/drug effects/*metabolism/radiation effects Neoplasm Staging Positron-Emission Tomography Rectal Neoplasms/diagnosis/diagnostic imaging/metabolism/*pathology/*therapy Retrospective Studies Tomography X-Ray Computed 03 medical and health sciences Radiology Nuclear Medicine and imaging human neoadjuvant therapy Dual time business.industry Rectal Neoplasms cancer staging Lean body mass corrected standardized uptake value Retrospective cohort study medicine.disease drug effects Lean body mass pathology business Nuclear medicine metabolism Chemoradiotherapy
Zdroj:	Nuclear medicine communications. 37(2)
ISSN:	1473-5628
Popis:	Objective The aim of this study was to evaluate, using PET/computed tomography (CT), changes in liver metabolic activity in patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (CRT). Patients and methods A total of 29 biopsy-proven LARC patients between 2009 and 2012 were studied. Liver standardized uptake values (SUVs) and SUVs adjusted for lean body mass (SULs) were obtained from PET/CT images obtained at 1 h (early) and 2 h (late) after 18F-fluorodeoxyglucose (18F-FDG) administration both before and after neoadjuvant CRT. Age, sex, BMI, lean body mass, blood glucose level, and 18F-FDG dose, which can influence liver SUVs and SULs, were also analyzed. Results Fourteen (48%) men and 15 (52%) women with a mean age of 62±11 years (range 34-80 years) were included in the study. The mean SUVs and SULs were significantly decreased in the late scans. Sex was significantly correlated with the mean liver SUV in early and late scans. The mean SUV differed significantly between male and female patients in early and late images (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896879330f42eda1131e15ea06932092 https://pubmed.ncbi.nlm.nih.gov/26440564 Zobrazit plný text záznamu