Altered β-adrenoceptor function associated to protein kinase C activation in hyperproliferative T lymphocytes
| Autor: | Claudia Anesini, Miriam R Wald, Claudia A. Cazaux, Leonor Sterin-Borda, Graciela Cremaschi, Tania Borda, Ana María Genaro |
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| Rok vydání: | 2000 |
| Předmět: |
Indoles
Neuroimmunomodulation T-Lymphocytes Immunology Adenylate kinase Stimulation Lymphocyte proliferation Biology Lymphoma T-Cell Cyclase Maleimides 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Receptors Adrenergic beta Tumor Cells Cultured Humans Immunology and Allergy Enzyme Inhibitors Receptor Protein Kinase C Protein kinase C Isoproterenol Adrenergic beta-Agonists Cell biology Enzyme Activation Neurology Neurology (clinical) Signal transduction Cell Division Intracellular Adenylyl Cyclases Signal Transduction |
| Zdroj: | Journal of Neuroimmunology. 110:57-65 |
| ISSN: | 0165-5728 |
| Popis: | beta-Adrenoceptor (betaAR) expression and function as well as its modulation via intracellular transduction signals, were analyzed on the T cell lymphoma BW5147. Independently to the kinetic of proliferation and relative to the number of receptors displayed in normal T lymphocytes, BW5147 cells displayed a decreased number of betaAR, uncoupled to adenylate cyclase, but coupled to protein kinase C stimulation. This last effect was impaired by a beta-antagonist and by blockers of the enzymatic pathways involved in T lymphocyte proliferation, inducing a recovery of betaAR sites. Down-regulation of betaAR would implicate the loss of a negative neuroimmune control mechanism for lymphocyte proliferation. The coupling of the remaining sites to a positive signal for cellular activation, would contribute to establish an hyperproliferative state. |
| Databáze: | OpenAIRE |
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