Neuronal circuits underlying acute morphine action on dopamine neurons
| Autor: | Romain Bourdy, Julien Courtin, François Georges, Pierre Veinante, Marion Jalabert, Olivier J. Manzoni, Michel Barrot |
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| Přispěvatelé: | Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie du système nerveux central - Institut François Magendie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Interdisciplinary Institute for Neuroscience (IINS), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Dopamine
[SDV]Life Sciences [q-bio] Glutamic Acid Pharmacology gamma-Aminobutyric acid 03 medical and health sciences Glutamatergic 0302 clinical medicine mental disorders medicine Animals gamma-Aminobutyric Acid 030304 developmental biology Neurons 0303 health sciences Multidisciplinary Morphine Chemistry Ventral Tegmental Area Dopaminergic Biological Sciences Rats 3. Good health Ventral tegmental area medicine.anatomical_structure Opioid Rostromedial tegmental nucleus nervous system GABAergic Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (39), pp.16446-50. ⟨10.1073/pnas.1105418108⟩ Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (39), pp.16446-50. ⟨10.1073/pnas.1105418108⟩ |
| ISSN: | 0027-8424 1091-6490 |
| Popis: | International audience; Morphine is a highly potent analgesic with high addictive potential in specific contexts. Although dopamine neurons of the ventral tegmental area (VTA) are widely believed to play an essential role in the development of drug addiction, neuronal circuits underlying morphine action on dopamine neurons have not been fully elucidated. Here we combined in vivo electrophysiology, tract-tracing experiments, and targeted neuronal inactivation to dissect a neural circuit for acute morphine action on dopamine neurons in rats. We found that in vivo, morphine targets the GABAergic tail of the VTA, also called the rostromedial tegmental nucleus, to increase the firing of dopamine neurons through the activation of VTA μ opioid receptors expressed on tail of the VTA/rostromedial tegmental nucleus efferents. Our data also reveal that in the absence of VTA glutamatergic tone, there is no morphine-induced activation of dopamine neurons. These results define the anatomical organization and functional role of a neural circuit for acute morphine action on dopamine neurons. |
| Databáze: | OpenAIRE |
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