Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance

Autor: Constantin Lapa, Franz Jakob, Bernhard Engelmann, F Genest, Johanna Strömsdörfer, Billy Sperlich, Lothar Seefried, Freerk T. Baumann, Franziska Jundt
Rok vydání: 2020
Předmět:
0301 basic medicine
Bone turnover
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Osteoporosis
Urology
Monoclonal gammopathy of undetermined significance
lcsh:RC254-282
Whole-body vibration
Physical performance
Bone remodeling
Dickkopf-1
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
N-terminal telopeptide
immune system diseases
Osteoclast
hemic and lymphatic diseases
medicine
cardiovascular diseases
Quantitative computed tomography
neoplasms
Bone mineral
medicine.diagnostic_test
business.industry
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Oncology
chemistry
030220 oncology & carcinogenesis
Sclerostin
lcsh:RC925-935
business
Research Article
Zdroj: Journal of Bone Oncology, Vol 25, Iss, Pp 100323-(2020)
Journal of Bone Oncology
ISSN: 2212-1374
DOI: 10.1016/j.jbo.2020.100323
Popis: Highlights • Whole-body vibration exercise improves physical performance in MGUS patients. • Muscle strength and endurance are improved after WBV in MGUS. • Whole-body vibration increases cortical bone mineral density in female participants. • Bone biomarkers show an adaptive response of the bone in MGUS after WBV.
Objective Monoclonal Gammopathy of Undetermined Significance (MGUS) is a risk factor for reduced physical performance, osteoporosis, and fractures due to compromised musculoskeletal metabolism. In this condition it is unknown whether whole-body vibration (WBV) exercise favorably alters physical performance and bone metabolism. Methods To evaluate the effect of three-months WBV exercise (30 min; 2x/week) including an optional three-month extension on physical performance, bone metabolism and bone mineral density. Endpoints included functional assessments, bone turnover markers and bone mineral density assessed by peripheral quantitative computed tomography of the tibia. Results Fifteen MGUS patients (median age 62.0, nine female) completed the first three months of which ten completed the three-month extension. Measures of physical functioning including chair rise test, timed up and go and 6-minute walk test improved (p = 0.007; p = 0.009; p = 0.005) after three and six months of WBV exercise. Total tibial bone mineral density remained unaltered (p > 0.05). WBV exercise tended to increase levels of sclerostin (p = 0.093) with a transient increase in osteoclast resorption markers (N-terminal telopeptide of collagen type 1, tartrate resistant acid phosphatase 5b) after three months while Dickkopf-1 (p = 0.093), procollagen I N-terminal propeptide (p = 0.074) and total alkaline phosphatase (p = 0.016) appeared to decline. No exercise-related adverse events were reported. Conclusion WBV exercise in MGUS patients improves indicators of physical performance. Observed trends in bone turnover markers and changes in distal tibial bone mineral density may indicate a regulatory effect of WBV exercise on bone metabolism and warrants further evaluation by large scale studies.
Databáze: OpenAIRE
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