Genetic determinism of parasitic circadian periodicity and subperiodicity in human lymphatic filariasis
| Autor: | Gaston Pichon, Jean-Pierre Treuil |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Population
Biorhythm Pantropical Zoology RYTHME BIOLOGIQUE medicine.disease_cause General Biochemistry Genetics and Molecular Biology Brugia malayi Genetic Determinism RELATION HOTE PARASITE Elephantiasis Filarial medicine Animals Humans Wuchereria bancrofti Circadian rhythm PARASITE education MUTATION Lymphatic filariasis MODELE MATHEMATIQUE education.field_of_study General Immunology and Microbiology biology COEVOLUTION VECTEUR General Medicine Models Theoretical GENETIQUE biology.organism_classification medicine.disease Circadian Rhythm DOMINANCE Mutation SIMULATION Mutation (genetic algorithm) MOUSTIQUE General Agricultural and Biological Sciences FILARIOSE LYMPHATIQUE |
| Zdroj: | Comptes Rendus Biologies. 327:1087-1094 |
| ISSN: | 1631-0691 |
| DOI: | 10.1016/j.crvi.2004.09.008 |
| Popis: | The larval parasites of the pantropical lymphatic filariasis exhibit two types of circadian behaviour. Typically, they only appear in the human bloodstream at nighttime, synchronised with their mosquito vectors. In Polynesia and parts of Southeast Asia, free of nocturnal vectors, they are found at all hours, and each population biorhythm differs. Through a geometrical approach, we explain this circadian diversity by a single, dominant mutation: the clocks of individual parasites are set at midnight (ubiquitous) or at 2 p.m. Compared to other circadian genes, this mutation must be very old, as it is shared by four biologically remote genera of parasites. This seniority sheds new light on several theoretical and practical aspects of vector-parasite temporal relations. |
| Databáze: | OpenAIRE |
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