A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers
| Autor: | Thomas H. Connor, Patricia I. Mathias, Clayton B'Hymer |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Health Personnel
Urinary system Clinical Biochemistry Antineoplastic Agents Pharmacology 01 natural sciences Biochemistry High-performance liquid chromatography Mass Spectrometry Article Analytical Chemistry 03 medical and health sciences Health personnel 0302 clinical medicine Liquid chromatography–mass spectrometry Occupational Exposure Health care Biological fluids Humans Chromatography High Pressure Liquid Chromatography business.industry Chemistry 010401 analytical chemistry Cell Biology General Medicine 030210 environmental & occupational health Anticancer drug Mass spectrometric 0104 chemical sciences business Biomarkers |
| Zdroj: | Journal of Chromatography B. 1060:316-324 |
| ISSN: | 1570-0232 |
| DOI: | 10.1016/j.jchromb.2017.06.028 |
| Popis: | The medical treatment of cancer with antineoplastic drugs is routine, but careful biomonitoring for these powerful drugs in individual healthcare worker exposure is necessary to ensure that engineering controls and exposure intervention measures are effective. This review describes published high performance liquid chromatography/mass spectrometry (HPLC-MS) methods for the determination of anticancer drugs in human urine as non-invasive tools for monitoring of healthcare worker exposure to antineoplastic and cytotoxic drugs. HPLC-MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC-MS methods are presented, as well as future trends and limitations in this area of research. |
| Databáze: | OpenAIRE |
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