Reactions between human serum gamma-globulin and zinc cations
| Autor: | E. E. Babaeva, E. A. Denisova, U. A. Vorob’eva, S. B. Cheknev |
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| Rok vydání: | 2005 |
| Předmět: |
Time Factors
Absorption spectroscopy Protein Conformation Ultraviolet Rays Inorganic chemistry chemistry.chemical_element Zinc General Biochemistry Genetics and Molecular Biology Metal Spectrophotometry Cations medicine Humans Binding site medicine.diagnostic_test Dose-Response Relationship Drug Proteins General Medicine Hydrogen-Ion Concentration Copper chemistry visual_art Intramolecular force visual_art.visual_art_medium gamma-Globulins Saturation (chemistry) Protein Binding |
| Zdroj: | Bulletin of experimental biology and medicine. 140(2) |
| ISSN: | 0007-4888 |
| Popis: | Interactions of human serum gamma-globulin with zinc cations in solution were studied by differential spectrophotometry in UV light. Supraphysiological concentrations of zinc caused an increment in optical density of protein solution reflecting the effect of gamma-globulin saturation with the metal. Zinc concentrations below physiological led to hypochromism in the protein absorption spectrum. Conformation changes in gamma-globulin during interactions with zinc are analyzed for the surface and intramolecular binding sites and are compared with the effects of copper cations. |
| Databáze: | OpenAIRE |
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