Magnetic resonance imaging of experimental testicular torsion
| Autor: | E. Mäkelä, Marko Kangasniemi, P. Ryymin, M Aaltonen, A. Kaipia, V. Kähärä |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Torsion Abnormality Urology Endocrinology Diabetes and Metabolism Gadolinium chemistry.chemical_element Testicular Diseases Rats Sprague-Dawley Testis Scrotum Animals Medicine Testicular torsion Effective diffusion coefficient Spermatic Cord Torsion medicine.diagnostic_test business.industry Torsion (mechanics) Magnetic resonance imaging Anatomy Blood flow medicine.disease Magnetic Resonance Imaging Rats body regions Disease Models Animal medicine.anatomical_structure Reproductive Medicine chemistry business Nuclear medicine Perfusion |
| Zdroj: | International Journal of Andrology. 28:355-359 |
| ISSN: | 1365-2605 0105-6263 |
| DOI: | 10.1111/j.1365-2605.2005.00576.x |
| Popis: | We investigated the feasibility of contrast enhanced (CE)-dynamic magnetic resonance imaging (MRI) for the detection of testicular torsion induced hypoperfusion in an experimental rat model. Adult Sprague-Dawley rats were subjected to unilateral testicular torsion of 360 or 720 degrees. After 1 h, the tail veins of the anaesthetized rats were cannulated and T2 -, diffusion-weighted and T1-weighted CE-dynamic MRI were subsequently performed by a 1.5 T MRI scanner. On apparent diffusion coefficient (ADC) images, the region of interest values of the ischaemic and control testes was compared. From CE-dynamic MR images, the maximal slopes of contrast enhancement were calculated and compared. In testicular torsion of 360 degrees, the maximal slope of contrast enhancement was 0.072%/s vs. 0.47%/s in the contralateral control testis (p < 0.001). A torsion of 720 degrees diminished the slope of contrast enhancement to 0.046%/s vs. 0.37%/s in the contralateral testis (p < 0.001). Diminished blood flow during torsion also followed in decreased ADC values in both 360 degrees (12.4% decrease; p < 0.05) and 720 degrees (10.8% decrease; p < 0.001) of torsion. Torsion of the testis causes ipsilateral hypoperfusion and decreased gadolinium uptake in a rat model that can be easily detected and quantified by CE-dynamic MRI. In diffusion-weighted MRI images, acute hypoperfusion results in a slight decrease of ADC values. Our results suggest that CE-dynamic MRI in combination with diffusion-weighted MRI can be used to detect compromised blood flow due to acute testicular torsion. |
| Databáze: | OpenAIRE |
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