Distinct actions of strontium on mineral formation in matrix vesicles

Autor: Jacqueline Radisson, Katia Bouchekioua-Bouzaghou, René Buchet, Laurence Bessueille, Géraldine Bechkoff
Přispěvatelé: Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Depierre, Frédérique
Rok vydání: 2008
Předmět:
Spectrophotometry
Infrared
Cations
Divalent
Biophysics
chemistry.chemical_element
030209 endocrinology & metabolism
Chick Embryo
Biochemistry
Pyrophosphate
Mineralization (biology)
Bone resorption
03 medical and health sciences
chemistry.chemical_compound
Adenosine Triphosphate
Calcification
Physiologic
0302 clinical medicine
Osteogenesis
Animals
Nucleotide
Bone Resorption
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
Molecular Biology
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
Strontium
Activator (genetics)
Secretory Vesicles
Vesicle
Cell Biology
Extracellular Matrix
Durapatite
chemistry
Alkaline phosphatase
Zdroj: Biochem. Biophys. Res. Comm.
Biochem. Biophys. Res. Comm., 2008, 373, pp.378-381
ISSN: 0006-291X
Popis: Matrix vesicles (MVs) are involved in the initial step of mineralization in skeletal tissues and provide an easily model to analyze the hydroxyapatite (HA) formation. Sr stimulates bone formation and its effect was tested on MVs. Sr 2+ (15–50 μM) in the mineralization medium containing MVs, 2 mM Ca 2+ and 3.42 mM P i , retarded HA formation. Sr 2+ (1–5 mM) in the same medium-induced other types of mineral than HA and cancelled the ATP-, ADP- or PP i -induced retardation in the mineral formation. Our findings suggest that the beneficial effect of Sr 2+ at a low dose (15–50 μM) is rather an inhibitor of bone resorption than an activator of mineral formation, while at high Sr 2+ concentration (1–5 mM), mineral formation, especially other types of mineral than HA, is favored.
Databáze: OpenAIRE
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