Possibilities of daytime anxolytics in the correction of residual neurological manifestations of COVID-19
| Autor: | S. V. Fomin, I. V. Borodacheva, E. A. Alexandrova, A. G. Suslov, K. M. Beliakov, V. S. Yulin, E. V. Parshina |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) business.industry Cognition General Medicine Autonomic disorder anxiety autonomic disorders medicine.disease medicine.disease_cause Affect (psychology) tofisopam Pharmacotherapy covid-19 Internal medicine medicine Medicine Anxiety sleep disorders asthenia medicine.symptom business Anxiety disorder Coronavirus |
| Zdroj: | Медицинский совет, Vol 0, Iss 12, Pp 50-60 (2021) |
| ISSN: | 2658-5790 2079-701X |
| DOI: | 10.21518/2079-701x-2021-12-50-60 |
| Popis: | Introduction. In addition to acute manifestations, coronavirus infection is characterized by long-lasting symptoms: asthenia, somatic vegetative manifestations, sleep disorders and psychoemotional background, the question of therapeutic correction of which is especially relevant.The aim of the study was to study the mental, somatoform and cognitive aspects of anxiety disorders after coronavirus infection during treatment with tofizopam (Grandaxin®) at 150 mg / day.Materials and methods. The study involved patients who had a new coronavirus infection, who 4 weeks after the end of treatment for the underlying disease had complaints that suggest the presence of an anxiety disorder. The Hamilton scale was used to assess the level of anxiety. The patients were examined before the start of treatment, after 2, 4 and 6 weeks of therapy.Results. Prior to the start of therapy, all patients had an overall high level of anxiety: the average HAM-A score was 31.72 ± 2.24 points. At the end of Grandaxin® therapy, all patients showed a decrease in the level of anxiety: the average score for HAM-A was 12.68 ± 2.04 points (p distinct – the average score on the “cognitive disorders” subscale decreased three times – from 1.6 ± 0.12 to 0.5 ± 0.09 (p˂0.001).Conclusions. Disorders of the psychoemotional background (more often in the form of increased personal anxiety), sleep disorders, autonomic disorders, asthenic syndrome significantly affect the quality of life of patients who have suffered a new coronavirus infection. A comprehensive approach is needed in the clinical diagnosis of the long-term consequences of a new coronavirus infection and their subsequent correction with drug therapy. |
| Databáze: | OpenAIRE |
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