Coordination of transcription, processing, and export of highly expressed RNAs by distinct biomolecular condensates
| Autor: | Aishwarya Gurumurthy, Alexander M. Ishov, Jörg Bungert |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Transcription
Genetic RNA polymerase II General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Super-enhancer Mediator Transcription (biology) super-enhancer nuclear pore complex Phosphorylation Nuclear pore Review Articles Gene 030304 developmental biology 0303 health sciences Gene Expression & Regulation Molecular Interactions biology Chemistry Cell biology RNA processing Cytoplasm biology.protein RNA RNA Polymerase II nuclear speckles phase separation transcription General Agricultural and Biological Sciences 030217 neurology & neurosurgery |
| Zdroj: | Emerging Topics in Life Sciences |
| ISSN: | 2397-8562 2397-8554 |
| DOI: | 10.1042/etls20190160 |
| Popis: | Genes under control of super-enhancers are expressed at extremely high levels and are frequently associated with nuclear speckles. Recent data suggest that the high concentration of unphosphorylated RNA polymerase II (Pol II) and Mediator recruited to super-enhancers create phase-separated condensates. Transcription initiates within or at the surface of these phase-separated droplets and the phosphorylation of Pol II, associated with transcription initiation and elongation, dissociates Pol II from these domains leading to engagement with nuclear speckles, which are enriched with RNA processing factors. The transitioning of Pol II from transcription initiation domains to RNA processing domains effectively co-ordinates transcription and processing of highly expressed RNAs which are then rapidly exported into the cytoplasm. |
| Databáze: | OpenAIRE |
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