Assessment of the half-life of cationic periodontal pocket irrigation
| Autor: | Safak Aygul, Ilker Keskiner, Murathan Sahin, Umur Sakallıoğlu, Gökhan Açikgöz, Banu Kirtiloglu, Tugrul Kirtiloglu |
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| Přispěvatelé: | OMÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Time Factors
Gingival and periodontal pocket Metabolic Clearance Rate Cationic irrigation Dentistry 030204 cardiovascular system & hematology Tallium-201 03 medical and health sciences 0302 clinical medicine Periodontal pocket Medicine Humans Periodontitis Radionuclide Imaging Therapeutic Irrigation General Dentistry business.industry Antimicrobial efficacy Cationic polymerization Half-life 030206 dentistry Antimicrobial medicine.disease Clearance time Scintigraphy lcsh:RK1-715 Thallium Radioisotopes lcsh:Dentistry business Research Article Half-Life |
| Zdroj: | BMC Oral Health BMC Oral Health, Vol 20, Iss 1, Pp 1-5 (2020) |
| ISSN: | 1472-6831 |
| Popis: | Background The concentration and persisting time of antimicrobial agents in the periodontal pockets are important factors for their antimicrobial efficacy. Increased clearance time in the periodontal pocket is a significant criterion for the selection of intrapocket irrigants. The aim of this study was to estimate the clearance time of a cationic agent from the periodontal pocket. Methods Thallium-201(Tl-201) was chosen as a tracer to simulate the clearance of cationic substance because of its electrical activity. Twenty patients with periodontitis and probing depths 6 to 9 mm were included in this study. In each patient, 3 Mega Becquerel (MBq) of Tl-201 were inserted into the periodontal pocket. Dynamic imaging was performed and clearance of radioactivity was measured. Results Clearance of radioactivity was 67.1 ± 16.9, 83.1 ± 13.9, 90.4 ± 10.4, 93.39 ± 8.0% at 30, 60, 90 and 120 min, respectively. Half-life of wash-out was determined as 20.3 ± 10.2 min. Conclusion The results of this study demonstrate that the half-life of the cationic solution applied subgingivally was approximately 20 min and labelling of oral irrigants with radiotracers may be used to determine their clearance in further research. |
| Databáze: | OpenAIRE |
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