Who's in control? Regulation of metabolism and pathogenesis in space and time
| Autor: | Alyssa N. King, Francois de Mets, Shaun R. Brinsmade |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
Virulence Factors Computational biology Cell Communication Biology Microbiology Virulence factor Article Pathogenesis 03 medical and health sciences Bacterial Proteins Gene expression Animals Humans Transcription factor 030304 developmental biology 0303 health sciences Bacteria Host Microbial Interactions Virulence 030306 microbiology RNA-Binding Proteins Metabolism Bacterial Infections Gene Expression Regulation Bacterial Infectious Diseases Sense and respond Cell metabolism Signal Transduction |
| Zdroj: | Curr Opin Microbiol |
| ISSN: | 1879-0364 |
| Popis: | Bacterial pathogens need to sense and respond to their environments during infection to align cell metabolism and virulence factor production to survive and battle host defenses. Complex regulatory networks including ligand-binding transcription factors, two-component systems, RNA-binding proteins, and small non-coding regulatory RNAs adjust gene expression programs in response to changes in metabolic fluxes, environmental cues, and nutrient availability. Recent studies underlined that these different layers of regulation occur along varying spatial and temporal scales, leading to changes in cell behavior and heterogeneity among the bacterial community. This brief review will highlight current research emphasizing that cell metabolism and pathogenesis are inextricably intertwined in both Gram-positive and Gram-negative bacteria. |
| Databáze: | OpenAIRE |
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