Antiarrhythmic Effects of JTV‐519, a Novel Cardioprotective Drug, on Atrial Fibrillation/Flutter in a Canine Sterile Pericarditis Model

Autor:	Naoki Gondo, Koichiro Kumagai, Keijiro Saku, Hideko Nakashima
Rok vydání:	2003
Předmět:	Male medicine.medical_specialty Cardiotonic Agents Thiazepines medicine.medical_treatment Drug Evaluation Preclinical Ischemia Antiarrhythmic agent Electrocardiography chemistry.chemical_compound Pericarditis Dogs Physiology (medical) Internal medicine Atrial Fibrillation Animals Medicine cardiovascular diseases business.industry P wave Effective refractory period JTV-519 Atrial fibrillation medicine.disease Treatment Outcome Atrial Flutter chemistry Anesthesia cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Atrial flutter
Zdroj:	Journal of Cardiovascular Electrophysiology. 14:880-884
ISSN:	1540-8167 1045-3873
DOI:	10.1046/j.1540-8167.2003.03050.x
Popis:	Introduction: A new cardioprotective drug, JTV-519, blocks Na+ current and inwardly rectifying K+ current and inhibits Ca2+ current. However, its role in atrial electrophysiology is unknown. We investigated the antiarrhythmic effects of JTV-519 on atrial fibrillation/flutter in the canine sterile pericarditis model. Methods and Results: In nine dogs with sterile pericarditis, 38 episodes of sustained (>30 sec) atrial fibrillation (8 dogs) and 24 episodes of sustained atrial flutter (7 dogs) were induced by rapid atrial pacing. When atrial fibrillation or atrial flutter was sustained >15 minutes, it was cardioverted and reinduced. The inducibility of atrial fibrillation/flutter, the atrial effective refractory period, and the intra-atrial conduction time were compared before and after the continuous infusion of JTV-519 (0.03 mg/kg/min). JTV-519 significantly decreased the mean number of sustained atrial fibrillation episodes (from 4.2 ± 2.9 to 0 ± 0, P < 0.01). In contrast, atrial flutter was still inducible in 4 dogs after JTV-519 (from 2.7 ± 2.5 to 1.6 ± 2.1, P = NS). JTV-519 significantly prolonged effective refractory period (from 123 ± 18 to 143 ± 14 msec, from 127 ± 18 to 151 ± 12 msec, and from 132 ± 13 to 159 ± 9 msec at basic cycle lengths of 200, 300, and 400 msec, respectively, P < 0.01), but it did not affect the intra-atrial conduction time (from 47 ± 11 msec to 48 ± 11 msec, P = NS). Conclusion: JTV-519 had significant protective effects on atrial fibrillation in the canine sterile pericarditis model, mainly by increasing effective refractory period, suggesting that it may have potential as a novel antiarrhythmic agent for atrial fibrillation. (J Cardiovasc Electrophysiol, Vol. 14, pp. 880-884, August 2003)
Databáze:	OpenAIRE
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