Analysis of proliferative activity using antiproliferating cell nuclear antigen antibody in colorectal cancer
| Autor: | Kazuo Miyamura, Hiroshi Yoshioka, Yoichi Saitoh, Takeshi Nakamura, Ryuichiro Ikegawa, Yoshiki Tabuchi, Junko Shirono, Kentaro Kawasaki, Shiro Nakae |
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| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty Colorectal cancer Metastasis Antigen Proliferating Cell Nuclear Antigen Carcinoma medicine Lymphatic vessel Humans Neoplasm Staging Chi-Square Distribution Ploidies biology business.industry Antibodies Monoclonal General Medicine DNA Neoplasm medicine.disease Flow Cytometry Prognosis Immunohistochemistry Proliferating cell nuclear antigen medicine.anatomical_structure Cell Transformation Neoplastic Oncology Lymphatic Metastasis biology.protein Surgery Antibody business Colorectal Neoplasms |
| Zdroj: | Journal of surgical oncology. 60(3) |
| ISSN: | 0022-4790 |
| Popis: | Using anti-PCNA antibody (PC10), an immunohistochemical study of the expression of PCNA in formalin-fixed and paraffin-embedded materials of colorectal cancer patients was performed and correlation of PCNA expression with clinicopathological findings and DNA ploidy pattern was studied. PCNA labeling rate (PCNA LR) was estimated in the advancing margin of the tumor and ranged from 23.8% to 77.9%. There was a significant difference in lymphatic vessel invasion, liver metastasis and Dukes' stage between the groups with high (>48.7) and low ( |
| Databáze: | OpenAIRE |
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