Interaction of dietary and genetic factors influencing body iron status and risk of type 2 diabetes within the EPIC-InterAct study
| Autor: | Kim Overvad, Courtney Dow, Amanda J. Cross, José María Huerta, Heiner Boeing, Elio Riboli, Karina Meidtner, Janine Kröger, Magdalena Stepien, Paula Jakszyn, Verena Katzke, Timothy J. Key, Guy Fagherazzi, Olle Melander, Francesca Mancini, Benedetta Bendinelli, Cecilie Kyrø, Domenico Palli, Marc J. Gunter, Paul W. Franks, Stephen J. Sharp, Salvatore Panico, Anne Tjønneland, Kay-Tee Khaw, Claudia Langenberg, Peter M. Nilsson, Mazda Jenab, Aurelio Barricarte, Rosario Tumino, Kim Ekblom, Matthias B. Schulze, J. Ramón Quirós, Yvonne T. van der Schouw, Tilman Kühn, Claudia Agnoli, Miguel Rodríguez-Barranco, Ivonne Sluijs, Carlotta Sacerdote, Clara Podmore, Nicholas J. Wareham, Larraitz Arriola, Nita G. Forouhi |
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| Přispěvatelé: | Podmore, Clara [0000-0002-2452-8067], Khaw, Kay-Tee [0000-0002-8802-2903], Forouhi, Nita [0000-0002-5041-248X], Sharp, Stephen [0000-0003-2375-1440], Langenberg, Claudia [0000-0002-5017-7344], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Imperial College Trust, Commission of the European Communities, Meidtner, Karina, Podmore, Clara, Kröger, Janine, Van Der Schouw, Yvonne T., Bendinelli, Benedetta, Agnoli, Claudia, Arriola, Larraitz, Barricarte, Aurelio, Boeing, Heiner, Cross, Amanda J., Dow, Courtney, Ekblom, Kim, Fagherazzi, Guy, Franks, Paul W., Gunter, Marc J., Huerta, José María, Jakszyn, Paula, Jenab, Mazda, Katzke, Verena A., Key, Timothy J., Khaw, Kay Tee, Kühn, Tilman, Kyrø, Cecilie, Mancini, Francesca Romana, Melander, Olle, Nilsson, Peter M., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Ramón Quirós, J., Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Sluijs, Ivonne, Stepien, Magdalena, Tjonneland, Anne, Tumino, Rosario, Forouhi, Nita G., Sharp, Stephen J., Langenberg, Claudia, Schulze, Matthias B., Riboli, Elio, Wareham, Nicholas J. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Hemochromatosis Protein/genetics Candidate gene Endocrinology Diabetes and Metabolism STORES Genome-wide association study Type 2 diabetes MEAT CONSUMPTION Cohort Studies Risk Factors Medicine 11 Medical and Health Sciences chemistry.chemical_classification biology Transferrin ASSOCIATION Middle Aged CANCER HEME Europe Female FERRITIN Life Sciences & Biomedicine PROJECT medicine.medical_specialty Iron Single-nucleotide polymorphism METABOLISM Polymorphism Single Nucleotide Article Europe/epidemiology Transferrin/genetics 03 medical and health sciences Endocrinology & Metabolism Internal medicine Journal Article Internal Medicine Humans Hemochromatosis Protein POLYMORPHISMS Genetic association Advanced and Specialized Nursing Science & Technology business.industry Transferrin saturation medicine.disease Diet Ferritin Ferritins/genetics 030104 developmental biology Endocrinology Cross-Sectional Studies Diabetes Mellitus Type 2/epidemiology chemistry Diabetes Mellitus Type 2 Ferritins biology.protein Gene-Environment Interaction business Iron/metabolism Genome-Wide Association Study |
| Zdroj: | Meidtner, K, Podmore, C, Kröger, J, van der Schouw, Y T, Bendinelli, B, Agnoli, C, Arriola, L, Barricarte, A, Boeing, H, Cross, A J, Dow, C, Ekblom, K, Fagherazzi, G, Franks, P W, Gunter, M J, Huerta, J M, Jakszyn, P, Jenab, M, Katzke, V A, Key, T J, Khaw, K T, Kühn, T, Kyrø, C, Mancini, F R, Melander, O, Nilsson, P M, Overvad, K, Palli, D, Panico, S, Quirós, J R, Rodriguez-Barranco, M, Sacerdote, C, Sluijs, I, Stepien, M, Tjonneland, A, Tumino, R, Forouhi, N G, Sharp, S J, Langenberg, C, Schulze, M B, Riboli, E & Wareham, N J 2018, ' Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study ', Diabetes Care, vol. 41, no. 2, pp. 277-285 . https://doi.org/10.2337/dc17-1080 Diabetes Care, 41(2), 277. American Diabetes Association Inc. |
| ISSN: | 0149-5992 |
| Popis: | OBJECTIVE Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression. RESULTS Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (−0.019 [−0.043; 0.006]) or transferrin saturation (0.016 [−0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03). CONCLUSIONS We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures. |
| Databáze: | OpenAIRE |
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