The Largest Single Center Report on Pediatric Liver Transplantation
| Autor: | Siavash Gholami, Alireza Shamsaeefar, Kourosh Kazemi, Seyed Mohsen Dehghani, Seyed Ali Malek-Hosseini, Hesameddin Eghlimi, Hamed Nikoupour, Ali Bahador, Saman Nikeghbalian, Masood Dehghani, Heshmatollah Salahi, Peyman Arasteh |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Iran Liver transplantation Single Center End Stage Liver Disease Sepsis 03 medical and health sciences Postoperative Complications 0302 clinical medicine Model for End-Stage Liver Disease Biliary atresia Interquartile range Internal medicine medicine Humans Child Retrospective Studies business.industry Age Factors Progressive familial intrahepatic cholestasis Infant medicine.disease Liver Transplantation Survival Rate Treatment Outcome Child Preschool 030220 oncology & carcinogenesis Etiology Female 030211 gastroenterology & hepatology Surgery business |
| Zdroj: | Annals of Surgery. 273:e70-e72 |
| ISSN: | 1528-1140 0003-4932 |
| DOI: | 10.1097/sla.0000000000004047 |
| Popis: | Objective We described our experiences on pediatric liver transplantation (LT) from the largest LT center in the world termed the Shiraz Transplant Center. Background After the first successful pediatric LT in 1967, pediatric LT has become the routine treatment for children with liver failure worldwide. Methods Data on a total of 1141 pediatric cases of LT were collected. Specifics on baseline and anthropometric characteristics, clinicopathology, prognosis of recipients of LT, and donor characteristics are reported. Results Mean age of patients was 7.83 ± 5.55 years old. Most common etiologies for LT were biliary atresia (15.9%), progressive familial intrahepatic cholestasis (13.4%), and Wilson's disease (13.3%), respectively.Whole organs, living donor grafts, and split grafts were used in 47.9%, 41%, and 11.1% of patients, respectively. In-hospital complications were seen among 34.7% of patients and the most common complications were infections (26.8%), bleeding (23.4%), and vascular complications (18%).Median (interquartile range) model for end stage liver disease score was 20 (15, 25). Main causes of death among patients were sepsis (35.2%), followed by post-transplantation lymphoproliferative diseases (10.5%), and primary nonfunction of liver (9%).Patient survival showed improvement over the years (1-year survival of 73.1%, 83.4%, and 84.4%, 2-year survival of 65.2%, 77.1%, and 78.7%, 5-year survival of 58.2%, 72%, and 77.8% for 1997-2007, 2007-2013, and 2013-2019, respectively; P Conclusions This is the largest single-center report on pediatric LT in literature which provides valuable experiences in pediatric LT. |
| Databáze: | OpenAIRE |
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