Systems pharmacology analysis of synergy of TCM: an example using saffron formula
| Autor: | Jingjing Liu, Zhenzhong Wang, Chunli Zheng, Jinglin Zhu, Yonghua Wang, Zonghui Qin, Jun Zhou, Yingxue Fu, Meng Jiang, Xuetong Chen, Wei Xiao, Chao Huang, Fengxia Shen, Jianling Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
food.ingredient ved/biology.organism_classification_rank.species lcsh:Medicine Traditional Chinese medicine Biology Article 03 medical and health sciences food Crocus sativus Drug Discovery Animals Humans Gene Regulatory Networks Medicine Chinese Traditional lcsh:Science ADME Crocus Biological Products Multidisciplinary Traditional medicine ved/biology Drug discovery Plant Extracts Systems Biology lcsh:R Biological activity Drug Synergism biology.organism_classification 030104 developmental biology Cardiovascular Diseases Herb lcsh:Q Systems pharmacology Drugs Chinese Herbal |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Traditional Chinese medicine (TCM) follows the principle of formulae, in which the pharmacological activity of a single herb can be enhanced or potentiated by addition of other herbs. Nevertheless, the involved synergy mechanisms in formulae remain unknown. Here, a systems-based method is proposed and applied to three representative Chinese medicines in compound saffron formula (CSF): two animal spices (Moschus, Beaver Castoreum), and one herb Crocus sativus which exert synergistic effects for cardiovascular diseases (CVDs). From the formula, 42 ingredients and 66 corresponding targets are acquired based on the ADME evaluation and target fishing model. The network relationships between the compounds and targets are assembled with CVDs pathways to elucidate the synergistic therapeutic effects between the spices and the herbs. The results show that different compounds of the three medicines show similar curative activity in CVDs. Additionally, the active compounds from them shared CVDs-relevant targets (multiple compounds-one target), or functional diversity targets but with clinical relevance (multiple compounds-multiple targets-one disease). Moreover, the targets of them are largely enriched in the same CVDs pathways (multiple targets-one pathway). These results elucidate why animal spices and herbs can have pharmacologically synergistic effects on CVDs, which provides a new way for drug discovery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|