Diiron Dithiolate Complex Induced Helical Structure of Histone and Application in Photochemical Hydrogen Generation
| Autor: | Fude Feng, Ke Du, Qiuyu Xia, Shuyi Li, Jian Sun, Weijian Chen, Xiantao Hu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine Diiron dithiolate Materials science biology Photochemistry Protein Conformation Ferric Compounds 01 natural sciences Catalysis Histones 03 medical and health sciences 030104 developmental biology Histone biology.protein General Materials Science Sulfhydryl Compounds Hydrogen 010606 plant biology & botany Hydrogen production |
| Zdroj: | ACS Applied Materials & Interfaces. 11:19691-19699 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.9b01866 |
| Popis: | Very-lysine-rich calf thymus histone proteins form disordered structure and hydrophobic interaction-driven aggregates in weakly acidic solution. We reported that the conjugation of diiron dithiolate complex to the lysine residues induced formation of helical conformation and condensed nanoassemblies with a high loading capacity up to 18.7 wt %. The incorporated diiron dithiolate complex showed photocatalytic activity for hydrogen evolution in aqueous solutions, with a turnover number (based on [FeFe] catalyst moiety) up to 359 that was more than 6 times that of the free catalyst. The increase of helical conformation in proteins was well correlated to the increasing enhancement of photocatalytic activity. We demonstrated that the [FeFe]-hydrogenase-mimic biohybrid system based on the photocatalyst-induced protein conformational conversion and reassembly is efficient for hydrogen generation regardless of the relatively large size. |
| Databáze: | OpenAIRE |
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