Dynamics of IL-4 and IFN-γ cytokine profile under the influence of combined allergen-specific immunotherapy (ASIT) in patients with polynosis and combined sensitization to pollen and household allergens
| Autor: | S. V. Biletska, E. M. Dytyatkovska |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
polynosis
cytokines combined allergen-specific immunotherapy polynosis business.industry medicine.medical_treatment lcsh:R cytokines combined allergen-specific immunotherapy lcsh:Medicine General Medicine Immunotherapy Disease medicine.disease_cause medicine.anatomical_structure Immune system Pollen Immunology otorhinolaryngologic diseases medicine Medical history In patient business Sensitization Interleukin 4 |
| Zdroj: | Медичні перспективи; Том 25, № 1 (2020); 116-121 Medicni perspektivi (Medical perspectives); Том 25, № 1 (2020); 116-121 Medičnì Perspektivi, Vol 25, Iss 1, Pp 116-121 (2020) |
| ISSN: | 2307-0404 |
| DOI: | 10.26641/2307-0404.2020.1.200410 |
| Popis: | The article presents the results of the clinical evaluation of the cytokine profile (IL-4, IFN-γ) in combined allergen-specific ASIT immunotherapy in patients with polynosis and combined sensitization to pollen and household allergens. Studies were conducted in 49 patients aged 19-57 years (24 women and 25 men) suffering from polynosis from 1 to 38 years. Patients underwent an allergological examination, including history taking, diagnostic skin tests - prick test, immunological studies of blood by enzyme-linked immunosorbent assay and allergic component diagnosis ALEX, on the basis of which polysensitization to pollen and household allergens was revealed in all patients. All patients underwent pre-season ASIT. The main group of 31 patients received a combined ASIT with solutions of pollen and household allegens. 18 patients of the comparison group received ASIT only with pollen allergens. The observation groups were comparable by sex, age, and disease duration. Studies were conducted during the period of remission of the disease before the onset of ASIT and 1 year after. It was found that under the influence of combined ASIT, an immunospecific effect was observed in patients with a significant decrease in the level of IL-4 in simultaneous increase in the production of interferon-gamma by 59.8%, which indicates the activation of the process of switching the immune response from Th-2 to Th-1 cells. The positive results of clinical and immunological studies convincingly prove the advantages and effectiveness of the use of ASIT in patients with polynosis and combined sensitization to pollen and household allergens. |
| Databáze: | OpenAIRE |
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