Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: A randomized, placebo-controlled pilot trial
| Autor: | Lauren M. Sippel, Amy E. Wahlquist, Megan M. Moran-Santa Maria, Sudie E. Back, Julianne C. Flanagan |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Implosive Therapy Poison control Pilot Projects Oxytocin Placebo Article Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Double-Blind Method Internal medicine Statistical significance Outcome Assessment Health Care Injury prevention medicine Humans Adverse effect Biological Psychiatry Depression (differential diagnoses) Veterans Prolonged exposure therapy business.industry Middle Aged Combined Modality Therapy 030227 psychiatry Psychiatry and Mental health Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Psychiatric Research. 98:64-69 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2017.12.014 |
| Popis: | Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition for which Prolonged Exposure (PE) therapy is highly efficacious. However, for some individuals, premature dropout and residual PTSD symptoms remain obstacles. The neuropeptide oxytocin is a promising candidate to enhance PE due to its ability to enhance 1) prosocial cognition and behavior, which are theorized to promote positive working alliance, and 2) extinction learning, which is the central mechanism of action underlying successful PE treatment. Despite a robust theoretical rationale, no studies to date have combined evidence-based psychotherapy for PTSD with oxytocin. This randomized, placebo-controlled, double-blind pilot trial examined the feasibility, safety, and preliminary efficacy of augmenting PE with oxytocin. Participants were 17 individuals with diverse index traumas. Participants self-administered intranasal oxytocin (40 IU) or matching placebo 45 min prior to each weekly PE therapy session. One adverse event occurred in the placebo group and three individuals dropped out (17.6%; 2 oxytocin group and 1 placebo group). The oxytocin group demonstrated lower PTSD and depression symptoms during PE, and had higher working alliance scores, although these differences did not reach statistical significance. Although preliminary, the findings support the feasibility of oxytocin combined with PE. Adequately powered studies are necessary to determine whether oxytocin enhances PE treatment outcomes and to examine potential mechanisms, such as accelerating extinction learning, enhancing early response, and preventing premature dropout. NCT03238924. |
| Databáze: | OpenAIRE |
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