Antimicrobial Peptide, LL-37, And Its Potential As An Anti-HIV Agent
| Autor: | Ana Vera-Cruz, Nongnuj Tanphaichitr, Jonathan B. Angel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Pore Forming Cytotoxic Proteins Anti hiv business.industry Anti-HIV Agents Antimicrobial peptides Human immunodeficiency virus (HIV) virus diseases Peptide General Medicine medicine.disease_cause Antimicrobial Anti-Bacterial Agents chemistry Cathelicidins Immunology medicine Anti-HIV Agent business Antimicrobial Cationic Peptides |
| Zdroj: | Clinical and investigative medicine. Medecine clinique et experimentale. 44(3) |
| ISSN: | 1488-2353 |
| Popis: | Human immunodeficiency virus (HIV) continues to have a profound global health impact. New infections continue at a high rate despite the development of prophylactic therapies, prompting the need for development of novel preventative approaches. Antimicrobial peptides (AMPs), such as LL-37, display broad microbicidal properties and have potential as anti-HIV agents. LL-37 has been studied for its anti-HIV activity and the limited data available suggest it can inhibit HIV infection in primary T cells as well as exert inhibitory effects on key HIV enzymes. Its immunomodulatory properties may both enhance and inhibit HIV replication. In addition, LL-37 has both 1) the ability to kill other sexually-transmitted pathogens and 2) spermicidal activity; thus, it is a good candidate for multipurpose prevention technology. Further investigation of its anti-HIV activity is warranted. |
| Databáze: | OpenAIRE |
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