Assessment of leg oedema by dynamic lymphoscintigraphy with intradermal injection of technetium-99m human serum albumin and load produced by standing
| Autor: | Kazuyoshi Suga, Naofumi Matsunaga, Norihiko Kume, Kazumi Motoyama, Nobuhiko Ogasawara, Akiko Hara |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Supine position Injections Intradermal Posture chemistry.chemical_element Technetium Scintigraphy Edema Occlusion Supine Position Humans Medicine Radiology Nuclear Medicine and imaging Lymphedema Intradermal injection Technetium Tc 99m Aggregated Albumin Aged Sodium Pertechnetate Tc 99m Aged 80 and over Leg medicine.diagnostic_test business.industry General Medicine Middle Aged Surgery Lymphatic system chemistry Female Radiopharmaceuticals medicine.symptom Nuclear medicine business Technetium-99m Lymphoscintigraphy Half-Life |
| Zdroj: | European Journal of Nuclear Medicine. 28:294-303 |
| ISSN: | 1619-7089 0340-6997 |
| DOI: | 10.1007/s002590000418 |
| Popis: | This study was a preliminary evaluation of the utility of dynamic lymphoscintigraphy with technetium-99m human serum albumin (HSA) and a load produced by standing in the assessment of lymphatic dysfunction in patients with leg oedema. The 71 subjects investigated included 53 patients with lymphoedema, six with venous occlusion alone and five with lymphovenous occlusion, as well as seven normal subjects. After intradermal injection of 99mTc-HSA into an interdigital space in each foot, dynamic scintigrams were recorded with the patient supine for 15 min. The subjects then stood in place and images were recorded for an additional 15 min. Relative changes in lymphatic tracer transport before and after standing were analysed on time-activity curves (TACs). This test was compared with a conventional test in a supine position in six patients with lymphoedema, and was repeated in five other patients with lymphoedema. It was found that in the normal limbs, a standing load activated tracer transport to the draining lymphatic vessels, resulting in a rapid stepwise increase in tracer activity, large spiking waves and a decreasing phase following a peak in tracer activity on TACs. In 59 lymphoedematous limbs, including some with a mild form of oedema without morphological abnormalities on scintigrams, this load failed to induce a sufficient activation of tracer transport, and the frequencies of each of the three normally appearing changes described above significantly decreased compared with those in the 14 normal limbs (P |
| Databáze: | OpenAIRE |
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