Donation of oocytes as treatment for infertility in patients with premature ovarian failure: awarded the 'Nicolau de Moraes Barros' prize for gynecology
| Autor: | Márcia Siste Campos, Ricardo L. R. Baruffi, Ana L. Mauri, Cláudia Guilhermino Pertersen, Jose Gonçalves Franco Junior, João Batista Alcântara Oliveira |
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| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Adult
Infertility medicine.medical_specialty media_common.quotation_subject lcsh:Medicine Ovary Primary Ovarian Insufficiency Pregnancy medicine Humans Menstrual cycle media_common Gynecology Oocyte Donaion Oocyte Donation business.industry lcsh:R Premature Ovarian Failure Embryo General Medicine medicine.disease Embryo transfer Premature ovarian failure medicine.anatomical_structure Gestation Female Menotropins business Infertility Female |
| Zdroj: | Sao Paulo Medical Journal v.112 n.1 1994 São Paulo medical journal Associação Paulista de Medicina instacron:APM Sao Paulo Medical Journal, Volume: 112, Issue: 1, Pages: 510-516, Published: MAR 1994 São Paulo Medical Journal, Vol 112, Iss 1, Pp 510-516 |
| Popis: | A total of 7 cycles of embryo transfer by oocyte donation were performed on 5 patients with premature ovary failure (POF). All donors were under 35 of age and the recipients average age was 38.6 years. For synchronization between donor and recipient a semi programmed menstrual cycle was used by means of oral contraceptive followed by ovarian stimulation of donor with clomiphene citrate and human menopausal gonadotrophin. The recipients were easily adjusted to the donors by a flexible model of gradually increasing doses of estradiol valerianate. The average number of oocytes donated was 3.14 and average embryo cleavage rate was 80.2%. The average number of embryos transferred was 2.57. Embryo implantation rate was 22.2%. Clinical gestations occurred in 57.1% of the cycles. This series is probably the first one in Brazilian literature on oocyte donation as treatment for infertility in patients with premature ovarian failure. Um total de 7 ciclos de transferência de embriões provenientes da doação de oócitos foram realizados em 5 pacientes portadoras de insuficiência ovariana precoce. As doadoras possuíam idade inferior a 35 anos, e as receptoras, apresentavam idade média de 38.6 anos. No esquema de sincronização entre doadora e receptora usou-se um ciclo semiprogramado com pílula, seguido de estimulação da doadora com citrato de clomifeno e gonadotrofina menopausal humana. As receptoras foram facilmente acopladas com as doadoras através de um modelo flexível de doses crescentes de valerianato de estradiol. O número médio de oócitos doados foi de 3.14, a taxa de clivagem embrionária média de 80.2%, sendo o número médio de embriões transferidos de 2.57. A taxa de implantação embrionária foi de 22,2%. As gestações clínicas ocorreram em 57,1% dos ciclos. Provavelmente, essa série é a primeira apresentada na literatura nacional sobre a doação de oócitos no tratamento da infertilidade em pacientes com insuficiência ovariana precoce. |
| Databáze: | OpenAIRE |
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