Red blood cell distribution width as a potential inflammatory marker in pediatric osteomyelitis
| Autor: | Irem Eldem, Mhd Hasan Almekdash, Obada Almadani, Fatma Levent, Mohamad M. Al-Rahawan |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Proc (Bayl Univ Med Cent) |
| ISSN: | 1525-3252 0899-8280 |
| Popis: | BACKGROUND: Red cell distribution width (RDW) has been used in the differential diagnosis of anemia and revealed to be a potential marker of inflammation. METHOD: We conducted a retrospective study of acute-phase reactant changes in correlation with RDW among pediatric patients with osteomyelitis. RESULTS: We identified 82 patients whose mean RDW increased on average by 1% during antibiotic therapy (mean 13.9% on admission, 95% CI 13.4–14.3, and 14.9% at the end of antibiotic therapy, 95% CI 14.5–15.4). Overall, the RDW was weakly correlated with absolute neutrophil count (r = −0.21, P = 0.001), erythrocyte sedimentation rate (r = −0.17, P = 0.007), and C-reactive protein (r = −0.21, P = 0.001). The generalized estimating equation model showed a weak negative correlation between RDW and C-reactive protein during the therapy duration (B= −0.03, P = 0.008). CONCLUSIONS: The mild increase in RDW, and its weak negative correlation with other acute-phase reactants during the study course, limits its utility as a therapy response marker in pediatric osteomyelitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|