The direct formation of glycosyl thiols from reducing sugars allows one-pot protein glycoconjugation

Autor:	Benjamin G. Davis, David P. Gamblin, Gonçalo J. L. Bernardes
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Glycosylation Chemistry fungi Carbohydrates Subtilisin food and beverages Organothiophosphorus Compounds General Medicine General Chemistry Catalysis Dioxanes chemistry.chemical_compound Organic chemistry Glycosyl Sulfhydryl Compounds
DOI:	10.1002/anie.200600685
Popis:	(Figure Presented) Sweet and easy: A one-pot method consisting of direct thionation (1) followed by thiol-mediated chemoselective ligation (2) can be used for site-selective protein glycosylation. This procedure, which uses the Lawesson reagent, has been shown to be fully compatible with unprotected sugars, the products of which can be directly used in a selenenylsulfide protein glycosylation strategy. © 2006 Wiley-VCH Verlag GmbH and Co. KGaA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8946e486af88434e9e2f3844234eec19 https://doi.org/10.1002/anie.200600685 Zobrazit plný text záznamu