On the quantification of local power densities in a new vibration bioreactor
| Autor: | Christian Heiss, Elisa Mele, David Valentin, Christoph Biehl, Charline Roehr, Wolfram A. Bosbach, Alexandre Presas |
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| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament de Mecànica de Fluids, Universitat Politècnica de Catalunya. CDIF - Centre de Diagnòstic Industrial i Fluidodinàmica, Universitat Politècnica de Catalunya. FLUIDS - Enginyeria de Fluids |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Work (thermodynamics)
Medical bacteriology 02 engineering and technology Dosimeters Bioreactors Electricity Medicine and Health Sciences Public and Occupational Health Biomechanics Fluids Multidisciplinary Physics Vibration bioreactor Classical Mechanics Dosímetres 021001 nanoscience & nanotechnology Vaccination and Immunization Finite element method Power (physics) Controllability Chemistry Oncology Physical Sciences Engineering and Technology Medicine 0210 nano-technology Biofilm forming bacteria Research Article Chemical Elements States of Matter Materials science Science Acoustics Immunology 0206 medical engineering Vibration Engineering Oncological therapies Resonance Microbiology Vibration Bioreactor Power density Mechanical Engineering Antibacterial Therapy Biology and Life Sciences Correction Biomecànica Liquids Bacteriology Models Theoretical equipment and supplies 020601 biomedical engineering Piezoelectricity Culture Media Biofilms Bacteriologia mèdica Preventive Medicine Bacterial Biofilms Aluminum Enginyeria mecànica::Mecànica de fluids [Àrees temàtiques de la UPC] |
| Zdroj: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) PLoS ONE PLoS ONE, Vol 16, Iss 1, p e0245768 (2021) |
| Popis: | We investigate the power densities which are obtainable locally in a vibration bioreactor. These reactor systems are of great relevance for research about oncological or antibacterial therapies. Our focus lies on the local liquid pressure caused by resonance vibration in the fluid contained by the reactor’s petri dish. We use for the excitation one piezoelectric patch which offer advantages concerning controllability and reproducibility, when compared to ultrasound. The experimental work is extended by finite element analyses of bioreactor details. The peaks of the vibration response for water, sodium chloride (0.1N Standard solution), and McCoy’s 5A culture medium are in good alignment. Several natural frequencies can be observed. Local power density can reach multiple times the magnitude used in ultrasound studies. Based on the observed local power densities, we are planning future work for the exposure of cell cultures to mechanical vibration. Peer Reviewed Objectius de Desenvolupament Sostenible::3 - Salut i Benestar |
| Databáze: | OpenAIRE |
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