The Self-Assembly of Anticancer Camptothecin-Dipeptide Nanotubes: A Minimalistic and High Drug Loading Approach to Increased Efficacy
Autor: | Carlo M. Croce, Hui-Lung Sun, Aileen Shieh, Yuan Sun, Mark W. Grinstaff, Jon R. Parquette, Se Hye Kim, Jonah A. Kaplan |
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Rok vydání: | 2014 |
Předmět: |
Drug
Cell Survival Stereochemistry media_common.quotation_subject Conjugated system Catalysis chemistry.chemical_compound Cell Line Tumor medicine Humans Prodrugs heterocyclic compounds neoplasms media_common chemistry.chemical_classification Drug Carriers Nanotubes Dipeptide Organic Chemistry Dipeptides General Chemistry Prodrug Antineoplastic Agents Phytogenic Combinatorial chemistry Irinotecan Nanomedicine Microscopy Fluorescence chemistry Camptothecin Self-assembly HT29 Cells Lactone medicine.drug |
Zdroj: | Chemistry - A European Journal. 21:101-105 |
ISSN: | 0947-6539 |
Popis: | S)-Camptothecin (CPT)-conjugated dipep- tides are reported that preassemble into nanotubes with diameters ranging from 80-120 nm. These nanoassemblies maintain a high (~ 47 %) drug loading and exhibit greater drug stability (i.e., resistance to lactone hydrolysis), and consequently greater efficacy against several human cancer cells (HT-29, A549, H460, and H23) in vitro com- pared with the clinically used prodrug irinotecan. A key and defining feature of this system is the use of the CPT- conjugated dipeptide as both the drug and precursor to the nanostructured carrier, which simplifies the overall fabrication process. |
Databáze: | OpenAIRE |
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