The effect of diet on Paraoxonase 1/Arylesterase activities in patients with disorders of galactose metabolism
| Autor: | Stylianos Tsakiris, Kleopatra H. Schulpis, Evangelos D. Papakonstantinou, George A. Karikas, Maria Kalogerakou, Anastasia Bartzeliotou |
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| Rok vydání: | 2007 |
| Předmět: |
Galactosemias
medicine.medical_specialty Endocrinology Diabetes and Metabolism Lipoproteins Blood lipids Antioxidants Arylesterase chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Child biology Apolipoprotein A-I business.industry Aryldialkylphosphatase Galactosephosphates Paraoxonase Galactose Metabolism PON1 Lipids Diet chemistry Spectrophotometry Case-Control Studies biology.protein Apolipoprotein A1 business Carboxylic Ester Hydrolases Follow-Up Studies |
| Zdroj: | Clinical endocrinology. 67(5) |
| ISSN: | 0300-0664 |
| Popis: | Summary Objective To investigate the effects of diet on the antiatherogenic enzyme Paraoxonase 1/Arylesterase (PON1/Aryl) activities in patients with disorders of galactose metabolism. Patients and methods Eleven poorly dietary controlled children with classical galactosaemia (GALT deficiency), 7 with epimerase deficiency and 12 with duarte 1 variant ‘off diet’ underwent clinical and laboratory investigations before and after 10 days on galactose restricted diet whereas controls (N = 20) were examined once. Serum lipids, lipoproteins and apolipoprotein A1 (ApoA1) were measured with routine methods, PON1/Aryl activities and total antioxidant status (TAS) spectrophotometrically, and galactose-1-phosphate (Gal-1-P) enzymatically. Results Lipids, lipoproteins, ApoA1, PON1/Aryl, TAS remained unaltered in all groups, except in those with classical galactosaemia pre- versus postdiet. In patients with classical galactosaemia, TAS, PON1, Aryl (0·98 ± 0·2 mmol/l, 60 ± 12 U/min/ml, 56 ± 16 KU/min/ml, respectively) were significantly reduced prediet as compared with those postdiet (1·63 ± 0·2 mmol/l, 136 ± 15 U/min/ml, 112 ± 18 KU/min/ml, respectively; P |
| Databáze: | OpenAIRE |
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