Gut Microbiota: A Pivotal Hub for Polyphenols as Antidepressants
| Autor: | Tongxi Zhuang, Li Yang, Nian Zhou, Ying Xu, Xinyi Gu, Mingmei Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Gut flora Pharmacology digestive system 01 natural sciences medicine Animals Humans Intestinal Mucosa biology Depression digestive oral and skin physiology 010401 analytical chemistry Polyphenols food and beverages General Chemistry biology.organism_classification Antidepressive Agents Small intestine Gastrointestinal Microbiome 0104 chemical sciences Bioavailability medicine.anatomical_structure Polyphenol General Agricultural and Biological Sciences 010606 plant biology & botany |
| Zdroj: | Journal of Agricultural and Food Chemistry. 68:6007-6020 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.0c01461 |
| Popis: | Polyphenols, present in a broad range of plants, have been thought to be responsible for many beneficial health effects, such as an antidepressant. Despite that polyphenols can be absorbed in the small intestine directly, most of them have low bioavailability and reach the large intestine without any modifications due to their complex structures. The interaction between microbial communities and polyphenols in the intestine is important for the latter to exert antidepressant effects. Gut microbiota can improve the bioavailability of polyphenols; in turn, polyphenols can maintain the intestinal barrier as well as the community of the gut microbiota in normal status. Furthermore, gut microbita catabolize polyphenols to more active, better-absorbed metabolites, further ameliorating depression through the microbial-gut-brain (MGB) axis. Based on this evidence, the review illustrates the potential role of gut microbiota in the processes of polyphenols or their metabolites acting as antidepressants and further envisions the gut microbiota as therapeutic targets for depression. |
| Databáze: | OpenAIRE |
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