Inhibition of interleukin‐12 and/or interleukin‐23 for the treatment of psoriasis: What is the evidence for an effect on malignancy?
| Autor: | Elizabeth N. Ergen, Nabiha Yusuf |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
T-Lymphocytes
Context (language use) Dermatology Biochemistry Interleukin-23 Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences Mice 0302 clinical medicine Immune system Viewpoint Psoriasis Neoplasms Interleukin 23 Product Surveillance Postmarketing Medicine cancer Animals Humans Molecular Biology Clinical Trials as Topic Immunity Cellular biology business.industry interleukin Models Immunological Receptors Interleukin-12 Interleukin psoriasis Receptors Interleukin medicine.disease Interleukin-12 3. Good health Viewpoints Disease Models Animal biological therapy 030220 oncology & carcinogenesis Immunology Interleukin 12 biology.protein Ustekinumab Dermatologic Agents Antibody business |
| Zdroj: | Experimental Dermatology |
| ISSN: | 1600-0625 0906-6705 |
| Popis: | Immune cells and cytokines play an important role in the pathogenesis of psoriasis. Interleukin‐12 (IL‐12) and IL‐23 promote cellular responses mediated by T cells, which contribute to an inflammatory loop responsible for the induction and maintenance of psoriatic plaques. Antibodies that inhibit IL‐12/23 or IL‐23 are key treatment options for patients with psoriasis. IL‐12 and IL‐23 also play a key role in immune responses to infections and tumors. A growing body of information from clinical trials, cohort studies, postmarketing reports, genetic studies and animal models provides insights into the potential biological relationships between IL‐12/23 inhibition and malignancies. We summarize this information in tables and provide some context for the interpretation of these data with the goal of informing dermatologists who are using IL‐12/23 or IL‐23 inhibitors to treat patients with psoriasis. |
| Databáze: | OpenAIRE |
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