Muscarinic Induction of Hippocampal Gamma Oscillations Requires Coupling of the M1 Receptor to Two Mixed Cation Currents
| Autor: | Alokesh Duttaroy, Chu-Xia Deng, Jai-Wei Gan, Jürgen Wess, Chris J. McBain, André Fisahn, Masahisa Yamada |
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| Jazyk: | angličtina |
| Předmět: |
Indoles
Pyridines Neuroscience(all) Hippocampal formation Cellular level Muscarinic Agonists Hippocampus Synaptic Transmission Ion Channels Membrane Potentials chemistry.chemical_compound Mice Biological Clocks Interneurons Muscarine Muscarinic acetylcholine receptor Potassium Channel Blockers Animals Receptor Cation Transport Proteins Mice Knockout General Neuroscience Pyramidal Cells Receptor Muscarinic M1 Cardiovascular Agents Muscarinic acetylcholine receptor M1 Cyclic AMP-Dependent Protein Kinases Immunohistochemistry Receptors Muscarinic In vitro Coupling (electronics) Pyrimidines chemistry Biophysics Nerve Net Neuroscience |
| Zdroj: | Neuron. (4):615-624 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/S0896-6273(02)00587-1 |
| Popis: | Oscillatory network activity at gamma frequencies is assumed to be of major importance in cortical information processing. Whereas the synaptic mechanisms of gamma oscillations have been studied in detail, the ionic currents involved at the cellular level remain to be elucidated. Here we show that in vitro gamma oscillations induced by muscarine require activation of M1 receptors on hippocampal CA3 pyramidal neurons and are absent in M1 receptor-deficient mice. M1 receptor activation depolarizes pyramidal neurons by increasing the mixed Na(+)/K(+) current I(h) and the Ca(2+)-dependent nonspecific cation current I(cat), but not by modulation of I(M). Our data provide important insight into the molecular basis of gamma oscillations by unequivocally establishing a novel role for muscarinic modulation of I(h) and I(cat) in rhythmic network activity. |
| Databáze: | OpenAIRE |
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