Inflammation and Inflammatory Cytokine Contribute to the Initiation and Development of Ulcerative Colitis and Its Associated Cancer
| Autor: | Chaoliu Dai, Ming Dong, Shuodong Wu, Dianbo Yao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adenoma medicine.medical_treatment Inflammation Adenocarcinoma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Immunology and Allergy Humans Colitis Intestinal Mucosa Interleukin 6 biology business.industry Gastroenterology Cancer Mucous membrane NF-κB medicine.disease Ulcerative colitis 030104 developmental biology Cytokine medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Immunology Colonic Neoplasms biology.protein Disease Progression Cytokines Colitis Ulcerative medicine.symptom business Biomarkers |
| Zdroj: | Inflammatory bowel diseases. 25(10) |
| ISSN: | 1536-4844 |
| Popis: | Dysregulated inflammatory responses play a pivotal role in the initiation, development, and progression of tumors, as demonstrated by the association between ulcerative colitis and the increased risk of colon carcinoma. In this review, the underlying mechanisms for the initiation and development of ulcerative colitis and colitis-associated cancer are described, mainly focusing on the inflammation and inflammatory cytokine. Disruption of the intestinal mucosal barrier and bacterial invasion resulted in intestinal inflammation; and further TLR4/NF-κB stimulation in intestinal epithelial cells, inflammatory cell infiltration, and inflammatory cytokine release all confer survival advantages to or promote abnormal proliferation in susceptible cells. Importantly, the respective roles of TLR4/NF-κB, TNF–α, and IL-6 in intestinal epithelial cells and inflammatory cells are summarized in detail. A thorough understanding of these molecular mechanisms may help researchers and clinicians to explore novel approaches for the prevention and treatment of colitis-associated cancer. |
| Databáze: | OpenAIRE |
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