The Effects of Synbiotic Supplementation on Serum Anti-Inflammatory Factors in the Survivors of Breast Cancer with Lymphedema following a Low Calorie Diet: A Randomized, Double-Blind, Clinical Trial
| Autor: | Ali Saneei Totmaj, Mitra Zarrati, Hadi Emamat, Leila Janani, Saeideh Vafa, Shahpar Haghighat, Zahra Salehi, Mehraban Navaei, Shapour Jaberzadeh, Maryam Izad |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Vascular Endothelial Growth Factor A Cancer Research medicine.medical_specialty medicine.drug_class Anti-Inflammatory Agents Medicine (miscellaneous) Breast Neoplasms Synbiotics Anti-inflammatory Double blind 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer Survivors Double-Blind Method Transforming Growth Factor beta Low calorie diet Internal medicine medicine Edema Humans Lymphedema Obesity skin and connective tissue diseases Caloric Restriction 030109 nutrition & dietetics Nutrition and Dietetics business.industry Overweight medicine.disease humanities Interleukin-10 Clinical trial 030220 oncology & carcinogenesis Female Adiponectin business Complication Biomarkers |
| Zdroj: | Nutrition and cancer. 74(3) |
| ISSN: | 1532-7914 |
| Popis: | Breast cancer-related lymphedema (BCRL) is a treatment-related inflammatory complication in breast cancer survivors (BCSs). This study was aimed to evaluate the effect of synbiotic supplementation on serum concentrations of IL-10, TGF-β, VEGF, adiponectin, and edema volume among overweight or obese BCSs with lymphedema following a low-calorie diet (LCD).In a randomized double-blind, controlled clinical trial, 88 obese and overweight BCSs women were randomized to synbiotic supplement (There were no significant differences among participants in the baseline, except for IL-10 and adiponectin. Post-intervention, no significant differences were observed regarding the anti-inflammatory markers, including IL-10, VEGF, adiponectin, and TGF-β between the groups. After 10 weeks of intervention edema volume significantly decreased in the synbiotic group; additionally, anthropometric measurements (body weight, BMI, body fat percent, and WC) decreased in both groups significantly (Synbiotic supplementation coupled with an LCD in a 10-week intervention had beneficial effects on increasing the serum TGF-β, IL-10, and adiponectin levels in women with BCRL. It also reduced arm lymphedema volume. Therefore, synbiotic supplementation can be effective in improving health status in BCRL patients. |
| Databáze: | OpenAIRE |
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