Time to remission from mild to moderate depressive symptoms: One year results from the EVIDENT-study, an RCT of an internet intervention for depression

Autor: Björn Meyer, Christina Späth, Johanna Schröder, Eik Vettorazzi, Steffen Moritz, Fritz Hohagen, Thomas Berger, Jan Philipp Klein, Wolfgang Greiner, Gerhard Andersson, Martin Hautzinger, Matthias Rose, Wolfgang Lutz
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
Adolescent
Remission
Experimental and Cognitive Psychology
One year follow-up
law.invention
Young Adult
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Intervention (counseling)
medicine
Humans
Single-Blind Method
610 Medicine & health
Psychiatry
Depressive symptoms
Depression (differential diagnoses)
Aged
Internet
Cognitive Behavioral Therapy
Depression
Proportional hazards model
business.industry
Remission Induction
Hazard ratio
Middle Aged
Combined Modality Therapy
Antidepressive Agents
030227 psychiatry
Psychiatry and Mental health
Clinical Psychology
Internet intervention
Cognitive behavior therapy
Female
The Internet
150 Psychology
business
Internet interventions
030217 neurology & neurosurgery
Zdroj: Behaviour Research and Therapy. 97:154-162
ISSN: 0005-7967
Popis: Background: Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period. Methods: A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months. Results: Remission rates over time were significantly higher in the intervention group (Cox regression: hazard ratio [HR] 1.31; p = 0.009). The intervention was more effective in the subgroup not taking antidepressant medication (Cox regression: HR 1.88; p < 0.001). PHQ-change from baseline was greater in the intervention group (linear mixed model [LMM]: p < 0.001) with the between-group effect gradually decreasing from d = 0.36 at three months to d = 0.13 at twelve months (LMM: group by time interaction: p < 0.001). Conclusion: This internet intervention can contribute to achieving remission in people with mild to moderate depressive symptoms, especially if they are not on antidepressant medication (Trial Registration: NCT01636752). (C) 2017 Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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