Time to remission from mild to moderate depressive symptoms: One year results from the EVIDENT-study, an RCT of an internet intervention for depression
Autor: | Björn Meyer, Christina Späth, Johanna Schröder, Eik Vettorazzi, Steffen Moritz, Fritz Hohagen, Thomas Berger, Jan Philipp Klein, Wolfgang Greiner, Gerhard Andersson, Martin Hautzinger, Matthias Rose, Wolfgang Lutz |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Remission Experimental and Cognitive Psychology One year follow-up law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Intervention (counseling) medicine Humans Single-Blind Method 610 Medicine & health Psychiatry Depressive symptoms Depression (differential diagnoses) Aged Internet Cognitive Behavioral Therapy Depression Proportional hazards model business.industry Remission Induction Hazard ratio Middle Aged Combined Modality Therapy Antidepressive Agents 030227 psychiatry Psychiatry and Mental health Clinical Psychology Internet intervention Cognitive behavior therapy Female The Internet 150 Psychology business Internet interventions 030217 neurology & neurosurgery |
Zdroj: | Behaviour Research and Therapy. 97:154-162 |
ISSN: | 0005-7967 |
Popis: | Background: Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period. Methods: A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months. Results: Remission rates over time were significantly higher in the intervention group (Cox regression: hazard ratio [HR] 1.31; p = 0.009). The intervention was more effective in the subgroup not taking antidepressant medication (Cox regression: HR 1.88; p < 0.001). PHQ-change from baseline was greater in the intervention group (linear mixed model [LMM]: p < 0.001) with the between-group effect gradually decreasing from d = 0.36 at three months to d = 0.13 at twelve months (LMM: group by time interaction: p < 0.001). Conclusion: This internet intervention can contribute to achieving remission in people with mild to moderate depressive symptoms, especially if they are not on antidepressant medication (Trial Registration: NCT01636752). (C) 2017 Elsevier Ltd. All rights reserved. |
Databáze: | OpenAIRE |
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