Plasma Metabolomics and Breast Cancer Risk over 20 Years of Follow-up among Postmenopausal Women in the Nurses' Health Study

Autor:	Kristen D. Brantley, Oana A. Zeleznik, Bernard Rosner, Rulla M. Tamimi, Julian Avila-Pacheco, Clary B. Clish, A. Heather Eliassen
Rok vydání:	2022
Předmět:	Postmenopause Logistic Models Oncology Risk Factors Epidemiology Case-Control Studies Humans Metabolomics Nurses Breast Neoplasms Female Article Follow-Up Studies
Zdroj:	Cancer Epidemiol Biomarkers Prev
ISSN:	1538-7755 1055-9965
DOI:	10.1158/1055-9965.epi-21-1023
Popis:	Background: Metabolite profiles provide insight into biologic mechanisms contributing to breast cancer development. We explored the association between prediagnostic plasma metabolites (N = 307) and invasive breast cancer among postmenopausal women in a nested case–control study within the Nurses' Health Study (N = 1,531 matched pairs). Methods: Plasma metabolites were profiled via LC/MS-MS using samples taken ≥10 years (distant, N = 939 cases) and Results: No individual metabolites were significantly associated with breast cancer risk. MSEA showed negative enrichment of cholesteryl esters at the distant timepoint [normalized enrichment score (NES) = −2.26; Padj = 0.02]. Positive enrichment of triacylglycerols (TAG) with Conclusions: Cholesteryl esters measured earlier in disease etiology were inversely associated with breast cancer. TAGs with many double bonds measured closer to diagnosis were inversely associated with breast cancer risk. Impact: The discovered associations between metabolite subclasses and breast cancer risk can expand our understanding of biochemical processes involved in cancer etiology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893aa0a3a902bd04ce053a0227234b54 https://doi.org/10.1158/1055-9965.epi-21-1023 Zobrazit plný text záznamu