Frailty is Associated With Frontal Cortex-Related Cognitive Function in Patients With Alzheimer Disease
| Autor: | Chiu Hsiang Wu, Yu Hsuan Wu, Yu San Chang, Chin Jen Wang, Hsin Ning Lee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Frontal cortex
Frailty Hand Strength business.industry Neuropsychology Cognition medicine.disease Frontal Lobe 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Alzheimer Disease medicine Humans In patient 030212 general & internal medicine Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of geriatric psychiatry and neurology. 35(4) |
| ISSN: | 0891-9887 |
| Popis: | Objective: We compared the cognitive functions of Alzheimer disease (AD) patients who were robust, frail or pre-frail and hypothesized that declines in frontal cortex-related neuropsychological function would be associated with frailty. Method: One hundred and sixty outpatients aged 65 years or older with mild AD were enrolled. Cognitive function was assessed using the Cognitive Ability Screening Instrument and further classified into 4 clusters (recent memory, frontal cortex cluster, posterior cortex cluster, and orientation). Other variables included depressive mood, daily activities, body mass index, handgrip strength (HGS), and normal gait speed (NGS). Results: Performance in daily activities, and slower NGS than robust group. Both the frail and pre-frail groups had lower HGS and more depressive symptoms than robust group. Generalized linear with ordinal logistic analysis showed that increment in age, slowing in NGS, and worse frontal cortex cluster function associated with being in a higher level of frailty. The patients with depression symptoms were the odds of being in a higher level of frailty compared to those without depression symptoms. Conclusions: In addition to physical and psychological symptoms, frailty is associated with specific cognitive domains in patients with AD. A multidimensional approach should be used to assess the impact of intervention programs focusing on frail patients with AD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|