Capillary physiology of human medulloblastoma
| Autor: | Jens Timmer, Peter C. Warnke, K. Kopitzki, Christoph B. Ostertag |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Medulloblastoma Cancer Research Chemotherapy Efflux rate business.industry medicine.medical_treatment Physiology Cancer Vascular permeability Blood flow Tumor vascularization medicine.disease Plasma volume Capillaries Capillary Permeability Oncology Antineoplastic Combined Chemotherapy Protocols Humans Medicine Female Cerebellar Neoplasms Child business |
| Zdroj: | Cancer. 107:2223-2227 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/cncr.22212 |
| Popis: | BACKGROUND. Advances in the treatment of medulloblastoma have largely been attributed to the introduction of chemotherapy, although Phase III trials have shown advantages for chemotherapy only in subgroups. Because the efficacy of chemotherapy depends on tumor vascularization, the vascular physiology of human medulloblastomas was evaluated. METHODS. Seven patients with histologically proven medulloblastomas underwent measurements of capillary permeability and vascular plasma volume using contrast-enhanced dynamic computer tomography. Regional blood flow was measured in 5 patients using xenon computed tomography (CT). RESULTS. The capillary permeability-surface product for water-soluble compounds ranged from 1.7 6 5.5 to 17.6 6 12.3 mL/g/min with a mean of 10.5 6 6.3 mL/g/ min. The vascular plasma volume ranged from 0.02 6 0.021 to 0.045 6 0.049 mL/g with a mean of 0.03 6 0.01 mL/g. The efflux rate ranged from 0.012 6 0.007 to 0.065 6 0.064 1/min with a mean of 0.039 6 0.020 1/min. Regional tumoral blood flow showed a mean of 19.86 6 6.8 mL/100g/min as compared with normal cerebellum with 45.4 6 12.03 mL/100g/min (P |
| Databáze: | OpenAIRE |
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