Case-based review: ependymomas in adults

Autor:	Stephen Lowe, Mark R. Gilbert, Timothy J. Kaufmann, Samuel Andersen, Bruce M. Frankel, David Cachia, Adriana Olar, Samuel Lewis Cooper, Derek R. Johnson
Rok vydání:	2018
Předmět:	Ependymoma Pathology medicine.medical_specialty business.industry Genetic heterogeneity Spinal Cord Ependymoma Central nervous system Medicine (miscellaneous) Review medicine.disease Spinal cord World health 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Molecular classification 030220 oncology & carcinogenesis Medicine medicine.symptom business Anaplasia 030217 neurology & neurosurgery
Zdroj:	Neuro-Oncology Practice. 5:142-153
ISSN:	2054-2585 2054-2577
DOI:	10.1093/nop/npy026
Popis:	Ependymomas are rare primary central nervous system (CNS) tumors in adults. They occur most commonly in the spinal cord, and have classically been graded histologically into World Health Organization (WHO) grades I, II, or III based on the level of anaplasia. Recent data are showing that genetic heterogeneity occurs within the same histological subgroup and that ependymomas arising from different CNS locations have different molecular signatures. This has renewed interest in developing targeting therapies based on molecular profiles especially given the variable outcomes with radiation and the poor results with cytotoxic agents. In this paper, we present the case of a 46-year-old woman with a classic presentation of spinal cord ependymoma and discuss the current histopathological and molecular classification for ependymomas as well as current guidelines for patient management.
Databáze:	OpenAIRE
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