Urinary estrogen excretion in Cushing's syndrome
| Autor: | O. H. Pearson, Charles D. West, Barbara Damast |
|---|---|
| Rok vydání: | 1958 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry Estrone Biochemistry Excretion Cushing syndrome chemistry.chemical_compound Endocrinology Estradiol Congeners Internal medicine medicine Adrenocortical carcinoma Humans Cushing Syndrome Climacteric Chemistry Biochemistry (medical) Estriol Estrogens medicine.disease Menopause Estrogen Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 18(1) |
| ISSN: | 0021-972X |
| Popis: | Since overproduction of estrogens could conceivably play a role in the pathologic physiology of Cushing’s syndrome, an attempt was made to isolate, identify, and quantitate the urinary estrogens excreted by a 58-year-old postmenopausal woman with metastatic adrenocortical carcinoma and Cushing’s syndrome. By means of countercurrent distribution and paper chromatography, estrone and estriol were identified and isolated in a fluorometrically homogeneous form. During the control period the patient excreted 5.7 micrograms of estrone and 34.2 micrograms of estriol daily as measured by photofluorometry. Upon the administration of ACTH, the excretion of estrone increased 12-fold and that of estriol 5-fold. The isolated estrogens were assayed for biologic activity and the positive results were in reasonable agreement quantitatively with the fluorometric measurements. The acetate derivatives of the isolated estrogens were prepared, and their behavior upon paper chromatography was found to be identical with that of... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|