The changing patterns of comorbidities associated with human immunodeficiency virus infection, a longitudinal retrospective cohort study of Medicare patients
| Autor: | Craig S. Mayer, Kin Wah Fung, Frank S. Rhame, Vojtech Huser, Nick Williams |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Maximum likelihood Human immunodeficiency virus (HIV) Observational Study HIV Infections Comorbidity medicine.disease_cause comorbidities Medicare acquired immune deficiency syndrome 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology mental disorders medicine Odds Ratio Prevalence Humans 030212 general & internal medicine Longitudinal Studies Aged Retrospective Studies Aged 80 and over Likelihood Functions human immunodeficiency virus business.industry Medicare beneficiary virus diseases HIV Retrospective cohort study General Medicine Odds ratio medicine.disease United States 030220 oncology & carcinogenesis Chronic Disease Binary regression Female business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | The objective of this paper is to determine the temporal trend of the association of 66 comorbidities with human immunodeficiency virus (HIV) infection status among Medicare beneficiaries from 2000 through 2016. We harvested patient level encounter claims from a 17-year long 100% sample of Medicare records. We used the chronic conditions warehouse comorbidity flags to determine HIV infection status and presence of comorbidities. We prepared 1 data set per year for analysis. Our 17 study data sets are retrospective annualized patient level case histories where the comorbidity status reflects if the patient has ever met the comorbidity case definition from the start of the study to the analysis year. We implemented one logistic binary regression model per study year to discover the maximum likelihood estimate (MLE) of a comorbidity belonging to our binary classes of HIV+ or HIV– study populations. We report MLE and odds ratios by comorbidity and year. Of the 66 assessed comorbidities, 35 remained associated with HIV– across all model years, 19 remained associated with HIV+ across all model years. Three comorbidities changed association from HIV+ to HIV– and 9 comorbidities changed association from HIV– to HIV+. The prevalence of comorbidities associated with HIV infection changed over time due to clinical, social, and epidemiological reasons. Comorbidity surveillance can provide important insights into the understanding and management of HIV infection and its consequences. |
| Databáze: | OpenAIRE |
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