Predictors for carotid and femoral artery intima-media thickness in a non-diabetic sleep clinic cohort

Autor: George Larcos, Kristina Kairaitis, Christopher Lambeth, Karen Byth, John R. Wheatley, Rita Perri, Nicole Campbell-Rogers, Manisha Verma, Sharon A. Lee, Terence C. Amis
Rok vydání: 2020
Předmět:
Male
Physiology
Blood Pressure
Femoral artery
Polysomnography
Cardiovascular Medicine
Vascular Medicine
Body Mass Index
Medical Conditions
Endocrinology
Medicine and Health Sciences
Clinical Neurophysiology
Multidisciplinary
medicine.diagnostic_test
Respiration
Apnea
Arteries
Femoral Artery
medicine.anatomical_structure
Carotid Arteries
Physiological Parameters
Cardiovascular Diseases
Breathing
Cohort
Cardiology
cardiovascular system
Medicine
Female
medicine.symptom
Anatomy
Artery
Research Article
Adult
medicine.medical_specialty
Endocrine Disorders
Science
Sleep Apnea Syndromes
Internal medicine
medicine.artery
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
cardiovascular diseases
business.industry
Body Weight
Biology and Life Sciences
Cardiovascular Disease Risk
Femoral Arteries
medicine.disease
nervous system diseases
respiratory tract diseases
Clinical trial
Intima-media thickness
Metabolic Disorders
Cardiovascular Anatomy
Blood Vessels
Clinical Medicine
business
Tunica Intima
Physiological Processes
Sleep
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252569 (2021)
ISSN: 1932-6203
Popis: Introduction The impact of sleep disordered breathing (SDB) on arterial intima-media thickness (IMT), a surrogate measure for cardiovascular disease, remains uncertain, in part because of the potential for non-SDB vascular risk factor interactions. In the present study, we determined predictors for common carotid (CCA) and femoral (CFA) artery IMT in an adult, sleep clinic cohort where non-SDB vascular risk factors (particularly diabetes) were eliminated or controlled. Methods We recruited 296 participants for polysomnography (standard SDB severity metrics) and CCA/CFA ultrasound examinations, followed by a 12 month vascular risk factor minimisation (RFM) and continuous positive pressure (CPAP) intervention for participants with a range of SDB severity (RFM Sub-Group, n = 157; apnea hyponea index [AHI]: 14.7 (7.2–33.2), median [IQR]). Univariable and multivariable linear regression models determined independent predictors for IMT. Linear mixed effects modelling determined independent predictors for IMT change across the intervention study. P Results Age, systolic blood pressure and waist:hip ratio were identified as non-SDB predictive factors for CCA IMT and age, weight and total cholesterol:HDL ratio for CFA IMT. No SDB severity metric emerged as an independent predictor for either CCA or CFA IMT, except in the RFM Sub-Group, where a 2-fold increase in AHI predicted a 2.4% increase in CFA IMT. Across the intervention study, CCA IMT decreased in those who lost weight, but there was no CPAP use interaction. CFA IMT, however, decreased by 12.9% (95%CI 6.8, 18.7%, p = 0.001) in those participants who both lost weight and used CPAP > = 4hours/night. Conclusion We conclude that SDB severity has little impact on CCA IMT values when non-SDB vascular risk factors are minimised or not present. This is the first study, however, to suggest a potential linkage between SDB severity and CFA IMT values. Trial registration Australian New Zealand Clinical Trials Registry, ACTRN12611000250932 and ACTRN12620000694910.
Databáze: OpenAIRE
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