Iloprost reduces colitis induced oxidative stress: An experimental study in rats
| Autor: | Erman Aytac, Seha Saygili, Hakki Oktay Seymen, Ertuğrul Göksoy, Volkan Sozer, Osman Baran Tortum, Serkan Teksoz, Hafize Uzun, Nihat Yavuz, Suha Goksel |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Antioxidant Colon medicine.medical_treatment Prostacyclin Pharmacology medicine.disease_cause Antioxidants chemistry.chemical_compound Random Allocation Malondialdehyde medicine Animals Iloprost Colitis Rats Wistar Acetic Acid business.industry Superoxide Dismutase Gastroenterology Glutathione medicine.disease Ulcerative colitis Rats Oxidative Stress chemistry Immunology cardiovascular system lipids (amino acids peptides and proteins) business Oxidative stress medicine.drug |
| Zdroj: | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 24(3) |
| ISSN: | 2148-5607 |
| Popis: | Background/aims: Reactive oxygen species have a known potent role in the pathogenesis of ulcerative colitis. Iloprost, a pharma- ceutical, is a chemically stable derivative of a naturally- occurring human prostacyclin. Several studies have demonstrated protec- tive effects of iloprost via its antioxidant and its anti-inflammatory activity. The aim of this study is to evaluate the effects of ilop- rost on oxidant/antioxidant status, as well as the large bowel histopathology in experimental colitis. Materials and Method: Forty adult male Wistar-albino rats were randomly divided in to four equal weight-matched groups: sham group (n=10), iloprost admi- nistered sham group (n=10), colitis group (n=10), iloprost administered colitis group (n=10). Acetic acid (1 ml of 4% solution) was used to induce colonic inflammation in the rats. Results: Colonic tissue and plasma malondialdehyde levels were significantly lo- wer in the iloprost administered colitis group than the colitis group (p |
| Databáze: | OpenAIRE |
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