Risk factors for local atypical fibroxanthoma recurrence and progression to pleomorphic dermal sarcoma: A meta‐analysis of individualized participant data

Autor: Mathias Ørholt, Frederik L. Aaberg, Kiya Abebe, S. Walsh, Randall K. Roenigk, Alessandro Venzo, Grethe Schmidt, Helle Klyver, David H. Jensen, Mikkel Herly, Peter V. Vester‐Glowinski
Rok vydání: 2022
Předmět:
Zdroj: Ørholt, M, Aaberg, F L, Abebe, K, Walsh, S, Roenigk, R K, Venzo, A, Schmidt, G, Klyver, H, Jensen, D H, Herly, M & Vester-Glowinski, P V 2022, ' Risk factors for local atypical fibroxanthoma recurrence and progression to pleomorphic dermal sarcoma : A meta-analysis of individualized participant data ', Journal of Surgical Oncology, vol. 126, no. 3, pp. 555-562 . https://doi.org/10.1002/jso.26898
ISSN: 1096-9098
0022-4790
DOI: 10.1002/jso.26898
Popis: BackgroundRisk factors for local atypical fibroxanthoma (AFX) recurrence and progression to pleomorphic dermal sarcoma (PDS) have not previously been identified.ObjectiveTo identify risk factors and provide follow-up suggestions for local AFX recurrence and progression to PDS.Methods and MaterialsA literature search was performed in the PubMed, EMBASE, and Cochrane databases. The PRISMA and MOOSE guidelines were followed. The risks of local AFX recurrence and progression to PDS were presented as Kaplan–Meier plots and risk factors were presented as hazard ratios (HRs) calculated with univariate and multivariate Cox regression.ResultsFive hundred and ninety-eight patients with AFX from 14 studies were included. Age >74 years and male sex significantly increased the risk of local recurrence (HR: 7.31 [95% confidence interval [CI]: 1.78–30.0], p ConclusionA more intensive follow-up regimen could be considered in patients >74 years old and males due to the higher risk of local AFX recurrence. BACKGROUND: Risk factors for local atypical fibroxanthoma (AFX) recurrence and progression to pleomorphic dermal sarcoma (PDS) have not previously been identified.OBJECTIVE: To identify risk factors and provide follow-up suggestions for local AFX recurrence and progression to PDS.METHODS AND MATERIALS: A literature search was performed in the PubMed, EMBASE, and Cochrane databases. The PRISMA and MOOSE guidelines were followed. The risks of local AFX recurrence and progression to PDS were presented as Kaplan-Meier plots and risk factors were presented as hazard ratios (HRs) calculated with univariate and multivariate Cox regression.RESULTS: Five hundred and ninety-eight patients with AFX from 14 studies were included. Age >74 years and male sex significantly increased the risk of local recurrence (HR: 7.31 [95% confidence interval [CI]: 1.78-30.0], p CONCLUSION: A more intensive follow-up regimen could be considered in patients >74 years old and males due to the higher risk of local AFX recurrence.
Databáze: OpenAIRE
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