The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels
| Autor: | J. B. A. Crusius, B A C Dijkmans, Michael T. Nurmohamed, R J van de Stadt, Paul P. Tak, I E van der Horst-Bruinsma, D. van Schaardenburg, G. M. Bartelds, Wouter H Bos, N. de Vries, Jennie Ursum, Gertjan Wolbink |
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| Přispěvatelé: | Rheumatology, CCA - Disease profiling, Pathology, Amsterdam institute for Infection and Immunity, Clinical Immunology and Rheumatology, Landsteiner Laboratory |
| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Immunology Lower risk Peptides Cyclic General Biochemistry Genetics and Molecular Biology Epitope Serology Arthritis Rheumatoid Epitopes Rheumatology immune system diseases Risk Factors Internal medicine medicine Immunology and Allergy Humans Allele skin and connective tissue diseases Aged Autoantibodies Aged 80 and over biology business.industry Arthritis HLA-DR Antigens Middle Aged medicine.disease Connective tissue disease Arthralgia Rheumatoid arthritis biology.protein Disease Progression Female Antibody business Biomarkers HLA-DRB1 Chains |
| Zdroj: | Annals of the Rheumatic Diseases, 67(9), 1347-1350. BMJ Publishing Group Bos, W H, Ursum, J, de Vries, N, Bartelds, G M, Wolbink, G J, Nurmohamed, M T, van der Horst-Bruinsma, I E, van de Stadt, R J, Crusius, J B A, Tak, P P, Dijkmans, B A C & van Schaardenburg, D 2008, ' The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels ', Annals of the Rheumatic Diseases, vol. 67, no. 9, pp. 1347-1350 . https://doi.org/10.1136/ard.2008.089953 Annals of the rheumatic diseases, 67(9), 1347-1350. BMJ Publishing Group |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2008.089953 |
| Popis: | OBJECTIVES: Patients presenting with both arthralgia and antibodies to cyclic citrullinated peptide (anti-CCP) have an increased risk of developing rheumatoid arthritis (RA). To further characterise this patient group and shed more light on its relationship with clinically manifest early arthritis and established RA, an immunogenetic and serological analysis was performed. METHODS: In a group of 111 patients with anti-CCP-positive arthralgia, anti-CCP levels and shared epitope (SE) status were determined. Data were compared with 125 and 128 patients with anti-CCP-positive early arthritis and established RA respectively. RESULTS: In patients with anti-CCP-positive arthralgia, the frequency of SE allele positivity is significantly lower when compared with anti-CCP-positive early arthritis and established RA (58% vs 80%, and 58% vs 92%, respectively, both p |
| Databáze: | OpenAIRE |
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