NT-proBNP in the Prognosis of Death or Need for Renal Replacement Therapy in Patients with Stage 3-5 Chronic Kidney Disease
Autor: | Leszek Gromadziński, Piotr Pruszczyk, Kamila Czarnacka, Beata Januszko-Giergielewicz |
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Rok vydání: | 2018 |
Předmět: |
Male
medicine.medical_specialty Time Factors Urology medicine.medical_treatment 030232 urology & nephrology 030204 cardiovascular system & hematology urologic and male genital diseases Risk Assessment 03 medical and health sciences 0302 clinical medicine Internal medicine Cause of Death Natriuretic Peptide Brain medicine Clinical endpoint Cutoff Humans In patient Renal replacement therapy Stage (cooking) Protein Precursors Renal Insufficiency Chronic Dialysis Aged Receiver operating characteristic business.industry medicine.disease Prognosis Peptide Fragments Renal Replacement Therapy Survival Rate ROC Curve Disease Progression Female Poland Cardiology and Cardiovascular Medicine business Biomarkers Kidney disease Follow-Up Studies |
Zdroj: | Cardiorenal medicine. 9(2) |
ISSN: | 1664-5502 |
Popis: | Background: The risk of cardiovascular (CV) complications is much greater in patients with chronic kidney disease (CKD). The aim of this study was to assess predictors of mortality, renal failure progression, and the need for dialysis in patients with CKD. Methods: The study group consisted of 70 patients with stage 3–5 CKD, followed up on average for 33.4 ± 15.6 months. Laboratory tests and echocardiography were performed on all patients. Composite endpoints were defined as (1) all-cause mortality and (2) mortality or renal replacement therapy (RRT), defined as the initiation of dialysis therapy. Results: During the observation period, 13 patients died and 11 began dialysis therapy. NT-proBNP was found to be a significant predictor in receiver operating characteristic curve analysis for all study endpoints. The optimal cutoff value for NT-proBNP as a predictor of mortality was 569.8 pg/mL, with a sensitivity of 53.8% and a specificity of 89.1%. For mortality or RRT, the cutoff value for NT-proBNP was 384.9 pg/mL, with a sensitivity and specificity of 70.8 and 72.7%, respectively. In a multivariate regression analysis, NT-proBNP was an independent predictor of mortality with an OR = 7.5 (95% CI: 1.05–53.87; p = 0.044) and of mortality or RRT with an OR = 4.7 (95% CI: 1.01–22.66; p = 0.048). Conclusions: NT-proBNP is an independent predictor of mortality in patients with CKD and can also be useful for CV risk stratification in this patient population. |
Databáze: | OpenAIRE |
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