The role of pH in salivary histidine-rich polypeptide antifungal germ tube inhibitory activity
| Autor: | R. P. Santarpia, J. J. Pollock, E. C. Brant |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Microbiology (medical)
chemistry.chemical_classification Saliva Antifungal Agents biology Immunology Germ tube Peptide Biological activity Hydrogen-Ion Concentration Spores Fungal biology.organism_classification Microbiology Yeast chemistry.chemical_compound chemistry Biochemistry Candida albicans Humans Imidazole Histidine Salivary Proteins and Peptides General Dentistry |
| Zdroj: | Oral Microbiology and Immunology. 5:336-339 |
| ISSN: | 1399-302X 0902-0055 |
| DOI: | 10.1111/j.1399-302x.1990.tb00437.x |
| Popis: | Purified synthetic salivary histidine-rich polypeptides (HRPs) 2, 3, 4, 5 and 6 were found to inhibit Candida albicans conversion of blastospores to germ tubes. HRP-4 was the best inhibitor within the pH 5 to 7 range tested and all of the HRPs were observed to lose potency as the pH was raised from 5 to 7. The pH pattern obtained with a synthetic homologous histidine peptide suggested that the protonated form of the histidine imidazole residues of the HRPs was important to the germ tube antifungal activity. Similar pH inhibition profiles of germ tube formation by parotid saliva and the HRPs were also observed. |
| Databáze: | OpenAIRE |
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