Cynomolgus monkey model for experimental Q fever infection
| Autor: | Richard A Kishimoto, Carl E. Pedersen, Edgar W. Larson, Janet C Gonder, Michael D. Kastello |
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| Rok vydání: | 1979 |
| Předmět: |
Male
Fluorescent Antibody Technique Q fever Pathogenesis Mice Coxiella biology.animal Sepsis Radiology Specialty medicine Immunology and Allergy Animals Primate Direct fluorescent antibody Aerosols biology Haplorhini Pneumonia bacterial infections and mycoses Coxiella burnetii biology.organism_classification medicine.disease Virology Antibodies Bacterial Radiography Disease Models Animal Macaca fascicularis Infectious Diseases Immunology biology.protein bacteria Macaca Female Antibody Q Fever Pneumonia (non-human) |
| Zdroj: | The Journal of infectious diseases. 139(2) |
| ISSN: | 0022-1899 |
| Popis: | A subhuman primate model was developed for study of the pathogenesis of infection with Coxiella burnetii. Cynomolgus monkeys (Macaca fascicularis) that were exposed to 10(5) mouse median infectious intraperitoneal doses of C. burnetii in a small-particle aerosol developed clinical signs of illness and pathologic changes characteristic of Q fever infection in humans. All monkeys had radiologic evidence of pneumonia by day 9. Antibodies to C. burnetii were detectable by the indirect fluorescent antibody test by day 7. These data indicate that the cynomolgus monkey is a suitable model for study of the pathogenesis of Q fever infection and may prove valuable in the evaluation of C. burnetii vaccines. |
| Databáze: | OpenAIRE |
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