A genetically engineered strain ofPseudomonas putidaas a useful tool for identifying new therapeutic herbicides
| Autor: | Mario Arcos, Sagrario Arias, José M. Luengo, Angel Sandoval, Elsa Arias-Barrau, Germán Naharro, ElÃas R. Olivera |
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| Rok vydání: | 2005 |
| Předmět: |
Molecular Sequence Data
Restriction Mapping Mutant Biology Microbiology Alkaptonuria Tyrosinemia chemistry.chemical_compound Gene cluster Genetics medicine Amino Acid Sequence Homogentisic acid Molecular Biology Chromatography High Pressure Liquid DNA Primers Homogentisate 1 2-dioxygenase Base Sequence Herbicides Pseudomonas putida Strain (biology) medicine.disease biology.organism_classification chemistry Biochemistry Mutagenesis Multigene Family Genetic Engineering Biotechnology |
| Zdroj: | FEMS Microbiology Letters. 249:297-302 |
| ISSN: | 1574-6968 0378-1097 |
| DOI: | 10.1016/j.femsle.2005.06.027 |
| Popis: | A genetically engineered strain of Pseudomonas putida U designed for the identification of new therapeutic herbicides has been obtained. In this bacterium, deletion of the homogentisate gene cluster (hmgRABC) confers upon this mutant huge biotechnological possibilities since it can be used: (i) as a target for testing new specific herbicides (p-hydroxy-phenylpyruvate dioxygenase inhibitors); (ii) to identify new therapeutic drugs-effective in the treatment of alkaptonuria and other related tyrosinemia - and (iii) as a source of homogentisic acid in a plant-bacterium association. |
| Databáze: | OpenAIRE |
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